公开(公告)号：US20240254572A1

公开(公告)日：2024-08-01

申请号：US18564575

申请日：2022-06-29

Applicant: Gen-Probe Incorporated

Inventor： Vincent J. CHABOT ,  Mark E. FILIPOWSKY

IPC: C12Q1/70 ,  C12Q1/6806 ,  C12Q1/6851

CPC classification number: C12Q1/701 ,  C12Q1/6806 ,  C12Q1/6851

Abstract: Disclosed are formulations and reaction mixtures comprising at least one polymerase, α-cyclodextrin, and polysorbate 20. Also disclosed are related methods for preparing the disclosed formulations and reaction mixtures, as well as related kits and methods for nucleic acid amplification. The formulations and reaction mixtures are useful, for example, in mitigating the inhibitory effect of sample extraction detergents on nucleic acid amplification reactions.