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公开(公告)号：US20100094195A1
公开(公告)日：2010-04-15
申请号：US12281495
申请日：2007-03-02
CPC分类号： A61L27/54 , A61K9/0009 , A61K9/0024 , A61L27/34 , A61L27/50 , A61L2300/608
摘要： A medicament containment device (106) is provided containing a medicament (114) and is associated with an implant, such as an orthopaedic implant (102). The medicament containment device (106) can degrade upon exposure to energy, such as energy (112) from an energy source (110). The orthopaedic implant (102), including the medicament containment device is implanted or inserted into an environment (100) such as a patient's body. The energy source (110) can be used outside the patient's body, but in proximity to the orthopaedic implant (102), to apply energy (112) to the medicament containment device (106). Upon exposure to the energy (112), the medicament containment device (106) can degrade and release the medicament (114) into the environment (100). The medicament (114) can kill and/or disrupt bacterial cells (108) or other infectious cells that form in proximity to the orthopaedic implant (102).
摘要翻译： 提供了药物容纳装置（106），其包含药物（114）并且与诸如整形外科植入物（102）的植入物相关联。 药物容纳装置（106）在暴露于来自能量源（110）的能量（例如能量（112））时可能降解。 包括药物容纳装置的整形外科植入物（102）被植入或插入诸如患者身体的环境（100）中。 能量源（110）可以在患者身体外部使用，但是在矫形外科植入物（102）附近，以将能量（112）施加到药物容纳装置（106）。 在暴露于能量（112）时，药物容纳装置（106）可以将药物（114）降解并释放到环境（100）中。 药物（114）可以杀死和/或破坏在整形外科植入物（102）附近形成的细菌细胞（108）或其它感染性细胞。
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公开(公告)号：US20080305144A1
公开(公告)日：2008-12-11
申请号：US12064156
申请日：2006-08-16
CPC分类号： A61L27/18 , A61L27/48 , A61L27/50 , A61L27/502 , C08L67/04
摘要： An oriented implantable, biodegradable device is disclosed. The oriented implantable, biodegradable device is formed from a homogeneous polymer blend comprising a polylactic acid in admixture, in an amount of not more than 10% by weight of the polymer blend, with an additive which both plasticises polymer draw and is a degradation accelerant. The polymer comprised within the blend may be a uniaxial, biaxial or triaxial orientation. Also disclosed is a composite thereof, processes for the preparation thereof, and The implantable biodegradable device may be used as a high strength trauma fixation device suitable for implantation into the human or animal body. As examples, the high strength trauma fixation device may take the form of plates, screws, pins, rods, anchors or scaffolds.
摘要翻译： 公开了一种定向可植入的可生物降解的装置。 面向可植入的可生物降解的装置由均匀的聚合物共混物形成，该共混物包含聚合物的混合物的聚乳酸，其量不超过聚合物共混物的10重量％，其中添加剂既塑化聚合物，并且是降解促进剂。 包含在共混物内的聚合物可以是单轴，双轴或三轴取向。 还公开了其复合物，其制备方法，并且可植入式可生物降解装置可以用作适合于植入人体或动物体内的高强度创伤固定装置。 作为示例，高强度创伤固定装置可以采取板，螺钉，销，杆，锚或支架的形式。
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