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    Therapeutic agents for the treatment of migraine
    5.
    发明授权
    Therapeutic agents for the treatment of migraine 有权
    用于治疗偏头痛的治疗剂

    公开(公告)号：US07772244B2

    公开(公告)日：2010-08-10

    申请号：US11091429

    申请日：2005-03-28

    申请人： Andrew P. Degnan ,  Xiaojun Han ,  Gene M. Dubowchik ,  John E. Macor ,  Stephen E. Mercer

    发明人： Andrew P. Degnan ,  Xiaojun Han ,  Gene M. Dubowchik ,  John E. Macor ,  Stephen E. Mercer

    IPC分类号： A61K31/517 ,  A61K31/47 ,  C07D215/227 ,  C07D239/80

    CPC分类号： C07D401/14

    摘要： The present invention relates to compounds of Formula (I) as antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their use in therapy for treatment of neurogenic vasodilation, neurogenic inflammation, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.

    摘要翻译： 本发明涉及作为降钙素基因相关肽受体（“CGRP受体”）拮抗剂的式（I）化合物，包含它们的药物组合物，鉴定它们的方法，使用它们的治疗方法及其在治疗治疗中的用途 神经源性血管舒张，神经源性炎症，偏头痛和其他头痛，热损伤，循环休克，与更年期相关的潮红，气道炎症性疾病如哮喘和慢性阻塞性肺疾病（COPD）以及其他治疗可以通过 CGRP受体的拮抗作用。

    CGRP receptor antagonists
    7.
    发明授权
    CGRP receptor antagonists 有权
    CGRP受体拮抗剂

    公开(公告)号：US08748429B2

    公开(公告)日：2014-06-10

    申请号：US13439096

    申请日：2012-04-04

    申请人： Guanglin Luo ,  Gene M. Dubowchik ,  John E. Macor ,  Ling Chen

    发明人： Guanglin Luo ,  Gene M. Dubowchik ,  John E. Macor ,  Ling Chen

    IPC分类号： A61K31/495 ,  A01N43/50 ,  A01N43/54 ,  A01N43/56 ,  A01N43/58

    CPC分类号： C07D471/04 ,  C07D487/04

    摘要： The disclosure generally relates to the novel compounds of formula I, including pharmaceutically acceptable salts, which are CGRP receptor antagonists. The disclosure also relates to pharmaceutical compositions and methods for using the compounds in the treatment of CGRP related disorders including migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases such as asthma, and chronic obstructive pulmonary disease (COPD).

    摘要翻译： 本公开内容通常涉及式I的新化合物，其包括药学上可接受的盐，其为CGRP受体拮抗剂。 本公开还涉及用于治疗CGRP相关疾病（包括偏头痛和其他头痛，神经源性血管舒张，神经源性炎症，热损伤，循环休克，与更年期相关的潮红，气道炎症性疾病如哮喘）的药物组合物和方法， 和慢性阻塞性肺疾病（COPD）。

    CGRP receptor antagonist
    8.
    发明授权
    CGRP receptor antagonist 有权
    CGRP受体拮抗剂

    公开(公告)号：US08481546B2

    公开(公告)日：2013-07-09

    申请号：US13038550

    申请日：2011-03-02

    申请人： Prasad V. Chaturvedula ,  Gene M. Dubowchik ,  John E. Macor

    发明人： Prasad V. Chaturvedula ,  Gene M. Dubowchik ,  John E. Macor

    IPC分类号： C07D401/14 ,  A61K31/496

    CPC分类号： C07D401/14 ,  C07K5/0806

    摘要： The disclosure generally relates to the compound of formula I, (R)—N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide, including pharmaceutically acceptable salts, which is a CGRP-receptor antagonist. The disclosure also relates to pharmaceutical compositions and methods for using the compound in the treatment of CGRP related disorders including migraine headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and cancer.

    摘要翻译： 本发明一般涉及式I化合物，（R）-N-（3-（7-甲基-1H-吲唑-5-基）-1-（4-（1-甲基哌啶-4-基）哌嗪-1-基） 哌啶-1-基）-1-氧代丙-2-基）-4-（2-氧代-1,2-二氢喹啉-3-基）哌啶-1-甲酰胺，包括药学上可接受的盐，其是CGRP-受体拮抗剂。 本公开还涉及用于治疗CGRP相关疾病的药物组合物和方法，包括偏头痛，神经源性血管舒张，神经源性炎症，热损伤，循环休克，与绝经相关的潮红，气道炎症性疾病如哮喘，慢性阻塞性 肺部疾病（COPD）和癌症。

    CGRP Receptor Antagonists
    9.
    发明申请
    CGRP Receptor Antagonists 有权

    公开(公告)号：US20130096130A1

    公开(公告)日：2013-04-18

    申请号：US13439096

    申请日：2012-04-04

    申请人： Guanglin Luo ,  Gene M. Dubowchik ,  John E. Macor ,  Ling Chen

    发明人： Guanglin Luo ,  Gene M. Dubowchik ,  John E. Macor ,  Ling Chen

    IPC分类号： C07D471/04

    CPC分类号： C07D471/04 ,  C07D487/04

    摘要： The disclosure generally relates to the novel compounds of formula I, including pharmaceutically acceptable salts, which are CGRP receptor antagonists. The disclosure also relates to pharmaceutical compositions and methods for using the compounds in the treatment of CGRP related disorders including migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases such as asthma, and chronic obstructive pulmonary disease (COPD).

    CGRP Receptor Antagonists
    10.
    发明申请
    CGRP Receptor Antagonists 有权
    CGRP受体拮抗剂

    公开(公告)号：US20110251223A1

    公开(公告)日：2011-10-13

    申请号：US12902714

    申请日：2010-10-12

    申请人： Guanglin Luo ,  Gene M. Dubowchik ,  John E. Macor

    发明人： Guanglin Luo ,  Gene M. Dubowchik ,  John E. Macor

    IPC分类号： A61K31/437 ,  C07D471/10 ,  A61P25/06 ,  C07D471/04

    CPC分类号： C07D401/12 ,  C07D471/04 ,  C07D471/10 ,  C07D471/20

    摘要： The disclosure generally relates to the novel compounds of formula I, including pharmaceutically acceptable salts, which are CGRP receptor antagonists. The disclosure also relates to pharmaceutical compositions and methods for using the compounds in the treatment of CGRP related disorders including migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases such as asthma, and chronic obstructive pulmonary disease (COPD).

    摘要翻译： 本公开内容通常涉及式I的新化合物，其包括药学上可接受的盐，其为CGRP受体拮抗剂。 本公开还涉及用于治疗CGRP相关疾病（包括偏头痛和其他头痛，神经源性血管舒张，神经源性炎症，热损伤，循环休克，与更年期相关的潮红，气道炎症性疾病如哮喘）的药物组合物和方法， 和慢性阻塞性肺疾病（COPD）。