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公开(公告)号:US10941199B2
公开(公告)日:2021-03-09
申请号:US15957157
申请日:2018-04-19
Applicant: Genentech, Inc.
Inventor: Liping L. Sun , Yvonne Man-Yee Chen , Mark S. Dennis , Allen J. Ebens, Jr. , Andrew Polson
Abstract: The invention provides anti-CD79b antibodies and methods of using the same.
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2.Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents for the treatment of hematopoietic malignancies 有权
Title translation: 磷酸肌醇3-激酶抑制剂化合物和用于治疗造血恶性肿瘤的化学治疗剂的组合公开(公告)号:US09335320B2
公开(公告)日:2016-05-10
申请号:US13968202
申请日:2013-08-15
Applicant: Genentech, Inc.
Inventor: Allen J. Ebens, Jr. , Lori Friedman
IPC: A61K31/519 , A61K39/395 , A61K31/33 , A61K31/535 , A61K31/70 , G01N33/50 , A61K45/06
CPC classification number: G01N33/5011 , A61K31/33 , A61K31/519 , A61K31/535 , A61K31/70 , A61K39/395 , A61K45/06 , A61K2300/00
Abstract: Combinations of PI3K inhibitor compounds having Formula I and chemotherapeutic agents, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for treating hematopoietic malignancies. Methods of using such combinations for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed
Abstract translation: 具有式I的PI3K抑制剂化合物和化学治疗剂的组合,包括立体异构体,几何异构体,互变异构体,代谢物及其药学上可接受的盐,可用于治疗造血恶性肿瘤。 公开了将这些组合用于体外,原位和体内诊断,预防或治疗哺乳动物细胞或相关病理条件中的这些疾病的方法
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公开(公告)号:US11732054B2
公开(公告)日:2023-08-22
申请号:US16790656
申请日:2020-02-13
Applicant: Genentech, Inc.
Inventor: Xiaocheng Chen , Mark S. Dennis , Allen J. Ebens, Jr. , Teemu T. Junttila , Robert F. Kelley , Mary A. Mathieu
IPC: C07K16/28 , C07K16/32 , A61K39/395 , C07K16/30 , A61K45/06 , A61K31/573 , A61K47/68 , A61K39/00
CPC classification number: C07K16/32 , A61K31/573 , A61K39/39558 , A61K45/06 , A61K47/6881 , C07K16/283 , C07K16/2809 , C07K16/2827 , C07K16/2863 , C07K16/2887 , C07K16/2896 , C07K16/30 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C07K2317/71 , C07K2317/73 , C07K2317/92
Abstract: The invention provides anti-cluster of differentiation 3 (CD3) antibodies and methods of using the same.
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公开(公告)号:US10174124B2
公开(公告)日:2019-01-08
申请号:US14574132
申请日:2014-12-17
Applicant: Genentech, Inc.
Inventor: Xiaocheng Chen , Mark S. Dennis , Allen J. Ebens, Jr. , Robert F. Kelley , Mary A. Mathieu , Liping L. Sun
IPC: A61K39/395 , C07K16/32 , C07K16/28 , C07K16/30 , A61K45/06 , A61K31/573 , A61K47/68 , A61K39/00
Abstract: The invention provides anti-cluster of differentiation 3 (CD3) antibodies and methods of using the same.
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公开(公告)号:US11530275B2
公开(公告)日:2022-12-20
申请号:US16790616
申请日:2020-02-13
Applicant: Genentech, Inc.
Inventor: Xiaocheng Chen , Mark S. Dennis , Allen J. Ebens, Jr. , Teemu T. Junttila , Robert F. Kelley , Mary A. Mathieu
IPC: C07K16/28 , C07K16/32 , A61K39/395 , C07K16/30 , A61K45/06 , A61K31/573 , A61K47/68 , A61K39/00
Abstract: The invention provides anti-cluster of differentiation 3 (CD3) antibodies and methods of using the same.
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公开(公告)号:US11186650B2
公开(公告)日:2021-11-30
申请号:US16144686
申请日:2018-09-27
Applicant: Genentech, Inc.
Inventor: Xiaocheng Chen , Mark S. Dennis , Allen J. Ebens, Jr. , Robert F. Kelley , Mary A. Mathieu , Liping L. Sun
IPC: A61P35/00 , C07K16/32 , C07K16/28 , A61K39/395 , C07K16/30 , A61K45/06 , A61K31/573 , A61K47/68 , A61K39/00
Abstract: The invention provides anti-cluster of differentiation 3 (CD3) antibodies and methods of using the same.
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公开(公告)号:US09975949B2
公开(公告)日:2018-05-22
申请号:US14960015
申请日:2015-12-04
Applicant: Genentech, Inc.
Inventor: Liping L. Sun , Yvonne Man-Yee Chen , Mark S. Dennis , Allen J. Ebens, Jr. , Andrew Polson
IPC: A61K39/395 , C07K16/28 , A61K47/68 , A61K39/00
CPC classification number: C07K16/2803 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07K16/2809 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/622 , C07K2317/92
Abstract: The invention provides anti-CD79b antibodies and methods of using the same.
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