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公开(公告)号:US10961313B2
公开(公告)日:2021-03-30
申请号:US16730018
申请日:2019-12-30
申请人: Genentech, Inc.
发明人: Philip E. Hass , Robert F. Kelley , Justin M. Scheer , Whitney Shatz , Devin Tesar , Menno van Lookeren Campagne
摘要: The disclosure relates to antibody-polymer conjugates comprising one or more anti-Factor D antibody variants, their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation.
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公开(公告)号:US20160017052A1
公开(公告)日:2016-01-21
申请号:US14700853
申请日:2015-04-30
申请人: GENENTECH, INC.
发明人: Robert F. Kelley , Menno van Lookeren Campagne , Justin M. Scheer , Philip E. Hass , Devin Tesar
IPC分类号: C07K16/40 , A61K9/00 , A61K39/395
CPC分类号: C07K16/40 , A61K9/0048 , A61K2039/505 , C07K2317/55 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要: The invention relates to anti-Factor D antibody variants, their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation.
摘要翻译: 本发明涉及抗因子D抗体变体,其生产及其在制备用于治疗与过量或不受控补体活化相关的疾病和病症的组合物和药物中的用途。
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公开(公告)号:US20160009791A1
公开(公告)日:2016-01-14
申请号:US14732243
申请日:2015-06-05
申请人: GENENTECH, INC.
CPC分类号: C07K16/18 , C07K14/47 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92 , G01N33/68 , G01N2333/47 , G01N2440/36
摘要: Anti-K63-linked polyubiquitin monoclonal antibodies, and methods for using the antibodies, are provided.
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公开(公告)号:US20160002353A1
公开(公告)日:2016-01-07
申请号:US14792236
申请日:2015-07-06
申请人: Genentech, Inc.
发明人: Ling-Ling An , Sek Chung Fung , Robert F. Kelley , Henry B. Lowman , Sanjaya Singh , Herren Wu
IPC分类号: C07K16/40
CPC分类号: C07K16/18 , A61K2039/505 , C07K16/40 , C07K2317/24 , C07K2317/50 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要: The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
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公开(公告)号:US20160002352A1
公开(公告)日:2016-01-07
申请号:US14792213
申请日:2015-07-06
申请人: Genentech, Inc.
发明人: Ling-Ling An , Sek Chung Fung , Robert F. Kelley , Henry B. Lowman , Sanjaya Singh , Herren Wu
IPC分类号: C07K16/40
CPC分类号: C07K16/18 , A61K2039/505 , C07K16/40 , C07K2317/24 , C07K2317/50 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要: The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
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公开(公告)号:US11530275B2
公开(公告)日:2022-12-20
申请号:US16790616
申请日:2020-02-13
申请人: Genentech, Inc.
发明人: Xiaocheng Chen , Mark S. Dennis , Allen J. Ebens, Jr. , Teemu T. Junttila , Robert F. Kelley , Mary A. Mathieu
IPC分类号: C07K16/28 , C07K16/32 , A61K39/395 , C07K16/30 , A61K45/06 , A61K31/573 , A61K47/68 , A61K39/00
摘要: The invention provides anti-cluster of differentiation 3 (CD3) antibodies and methods of using the same.
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公开(公告)号:US11186650B2
公开(公告)日:2021-11-30
申请号:US16144686
申请日:2018-09-27
申请人: Genentech, Inc.
发明人: Xiaocheng Chen , Mark S. Dennis , Allen J. Ebens, Jr. , Robert F. Kelley , Mary A. Mathieu , Liping L. Sun
IPC分类号: A61P35/00 , C07K16/32 , C07K16/28 , A61K39/395 , C07K16/30 , A61K45/06 , A61K31/573 , A61K47/68 , A61K39/00
摘要: The invention provides anti-cluster of differentiation 3 (CD3) antibodies and methods of using the same.
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公开(公告)号:US10738106B2
公开(公告)日:2020-08-11
申请号:US15071422
申请日:2016-03-16
申请人: Genentech, Inc.
摘要: The invention provides anti-polyubiquitin antibodies and methods of using the same.
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公开(公告)号:US10421822B2
公开(公告)日:2019-09-24
申请号:US16168503
申请日:2018-10-23
申请人: Genentech, Inc.
发明人: Robert F. Kelley , Daniel K. Kirchhofer , Joyce Lai , Chingwei V. Lee , Wei-Ching Liang , Michael T. Lipari , Kelly M. Loyet , Tao Sai , Menno Van Lookeren Campagne , Yan Wu , Germaine Fuh
IPC分类号: C07K16/40 , A61K39/395 , A61K39/00
摘要: The present invention provides anti-HtrA1 antibodies (including bispecific anti-HtrA1 anti-Factor D antibodies) and methods of making and using the same, for example, in methods of treating HtrA1-associated disorders, ocular disorders, and/or complement-associated disorders.
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公开(公告)号:US20190023774A1
公开(公告)日:2019-01-24
申请号:US16021248
申请日:2018-06-28
申请人: Genentech, Inc.
摘要: Anti-K63-linked polyubiquitin monoclonal antibodies, and methods for using the antibodies, are provided.
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