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    INHIBITION OF IL-17 PRODUCTION
    1.
    发明申请
    INHIBITION OF IL-17 PRODUCTION 审中-公开

    公开(公告)号：US20190092829A1

    公开(公告)日：2019-03-28

    申请号：US15957879

    申请日：2018-04-19

    Applicant: Genentech, Inc.

    Inventor： Austin L. GURNEY

    IPC: C07K14/54 ,  A61K39/395

    Abstract: The invention concerns inhibition of the production of proinflammatory cytokine interleukin-17 (IL-17) by T cells, using an antagonist of interleukin-23 (IL-23). The invention further concerns the use of IL-23 antagonists in the treatment of inflammatory diseases characterized by the presence of elevated levels of IL-17. IL-23 antagonists include, without limitation, antibodies specifically binding to a subunit or IL-17 or an IL-17 receptor. The invention additionally concerns induction of IL-7 production by using an IL-23 agonist.

    IL-17A/F HETEROLOGOUS POLYPEPTIDES AND THERAPEUTIC USES THEREOF
    2.
    发明申请
    IL-17A/F HETEROLOGOUS POLYPEPTIDES AND THERAPEUTIC USES THEREOF 审中-公开

    公开(公告)号：US20190100583A1

    公开(公告)日：2019-04-04

    申请号：US15965115

    申请日：2018-04-27

    Applicant: Genentech, Inc.

    Inventor： David P. ARNOTT ,  Austin L. GURNEY ,  Philip E. HASS ,  James M. LEE ,  Yan WU

    IPC: C07K16/24 ,  C07K14/54 ,  G01N33/68 ,  A61K38/00

    Abstract: The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

    IL-17A/F HETEROLOGOUS POLYPEPTIDES AND THERAPEUTIC USES THEREOF
    4.
    发明申请
    IL-17A/F HETEROLOGOUS POLYPEPTIDES AND THERAPEUTIC USES THEREOF 审中-公开
    IL-17A / F异源多肽及其治疗方法

    公开(公告)号：US20170073409A1

    公开(公告)日：2017-03-16

    申请号：US14718039

    申请日：2015-05-20

    Applicant: GENENTECH, INC.

    Inventor： David P. ARNOTT ,  Austin L. GURNEY ,  Philip E. HASS ,  James M. LEE ,  Yan WU

    IPC: C07K16/24

    CPC classification number: C07K16/244 ,  A61K38/00 ,  C07K14/54 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/32 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/75 ,  C07K2317/76 ,  G01N33/6869 ,  Y02A50/463 ,  Y02A50/473

    Abstract: The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

    Abstract translation: 本发明涉及一种新型天然存在的人类细胞因子，其由本文称为白细胞介素17A / F（IL-17A / F）的白细胞介素-17和白细胞介素-17F的异源二聚体组成。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，与本发明的多肽结合的特异性抗体和用于产生 本发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。

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