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公开(公告)号：US20170320926A1
公开(公告)日：2017-11-09
申请号：US15454662
申请日：2017-03-09
申请人： Genentech, Inc.
发明人： Justin SCHEER , Wenjun OUYANG , Richard VANDLEN , Philip E. HASS , Eric Gary STEFANICH , Ganesh A. KOLUMAM , Xiaoting WANG , Jed ROSS , Nicholas VAN BRUGGEN , Wyne P. LEE
摘要： The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.
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公开(公告)号：US20190177388A1
公开(公告)日：2019-06-13
申请号：US16196823
申请日：2018-11-20
申请人： Genentech, Inc.
发明人： Justin SCHEER , Wenjun OUYANG , Richard VANDLEN , Philip E. HASS , Eric Gary STEFANICH , Ganesh A. KOLUMAM , Xiaoting WANG , Jed ROSS , Nicholas VAN BRUGGEN , Wyne P. LEE
摘要： The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.
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公开(公告)号：US20180362608A1
公开(公告)日：2018-12-20
申请号：US15801867
申请日：2017-11-02
申请人： Genentech, Inc.
发明人： Justin SCHEER , Wenjun OUYANG , Richard VANDLEN , Philip E. HASS , Eric Gary STEFANICH , Ganesh A. KOLUMAM , Xiaoting WANG , Jed ROSS , Nicholas VAN BRUGGEN , Wyne P. LEE
摘要： The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.
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公开(公告)号：US20190177386A1
公开(公告)日：2019-06-13
申请号：US16196741
申请日：2018-11-20
申请人： Genentech, Inc.
发明人： Justin SCHEER , Wenjun OUYANG , Richard VANDLEN , Philip E. HASS , Eric Gary STEFANICH , Ganesh A. KOLUMAM , Xiaoting WANG , Jed ROSS , Nicholas VAN BRUGGEN , Wyne P. LEE
摘要： The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.
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公开(公告)号：US20170291940A1
公开(公告)日：2017-10-12
申请号：US15360803
申请日：2016-11-23
申请人： Genentech, Inc.
发明人： David P. ARNOTT , Mercedes Z. BALAZS , Nico GHILARDI , Austin L. GURNEY , Philip E. HASS , Sarah HYMOWITZ , James M. LEE , Wenjun OUYANG , Melissa A. STAROVASNIK , Yan WU
IPC分类号： C07K16/24
CPC分类号： C07K16/244 , A61K38/2073 , A61K2039/505 , C07K14/54 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/40 , G01N2500/10 , G01N2800/24 , Y02A50/463
摘要： The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
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公开(公告)号：US20180355009A1
公开(公告)日：2018-12-13
申请号：US16049633
申请日：2018-07-30
申请人： Genentech, Inc.
CPC分类号： C07K14/54 , A61K31/573 , A61K38/20 , A61K45/06 , A61P1/04 , C07K7/06 , C07K2319/30
摘要： The invention relates to IL-22 Fc fusion protein, composition comprising the IL-22 Fc fusion protein, and method of using the composition for the treatment of diseases, especially inflammatory bowel diseases.
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公开(公告)号：US20170088596A1
公开(公告)日：2017-03-30
申请号：US15369236
申请日：2016-12-05
申请人： Genentech, Inc.
发明人： Justin SCHEER , Wenjun OUYANG , Richard VANDLEN , Philip E. HASS , Eric Gary STEFANICH , Ganesh A. KOLUMAM , Xiaoting WANG , Jed ROSS , Nicholas VAN BRUGGEN , Wyne P. LEE
IPC分类号： C07K14/54
CPC分类号： C07K14/54 , A61K38/00 , A61K38/20 , A61K47/38 , C07K16/2866 , C07K2319/30
摘要： The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.
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8.发明申请IL-22 POLYPEPTIDES AND IL-22 Fc FUSION PROTEINS AND METHODS OF USE 审中-公开IL-22多聚酶和IL-22 Fc融合蛋白及其使用方法公开(公告)号：US20170008942A1
公开(公告)日：2017-01-12
申请号：US15217790
申请日：2016-07-22
申请人： Genentech, Inc.
发明人： Justin SCHEER , Wenjun OUYANG , Richard VANDLEN , Philip E. HASS , Eric Gary STEFANICH , Ganesh A. KOLUMAM , Xiaoting WANG , Jed ROSS , Nicholas VAN BRUGGEN , Wyne P. LEE
CPC分类号： C07K14/54 , A61K38/00 , A61K38/20 , A61K47/38 , C07K16/2866 , C07K2319/30
摘要： The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.
摘要翻译： 本发明涉及IL-22多肽，IL-22 Fc融合蛋白和IL-22激动剂，包含其的组合物，制备方法和使用该组合物治疗疾病的方法。 本发明还涉及IL-22受体相关试剂及其使用方法。
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公开(公告)号：US20230063741A1
公开(公告)日：2023-03-02
申请号：US17721970
申请日：2022-04-15
申请人： Genentech, Inc.
发明人： Justin SCHEER , Wenjun OUYANG , Richard VANDLEN , Philip E. HASS , Eric Gary STEFANICH , Ganesh A. KOLUMAM , Xiaoting WANG , Jed ROSS , Nicholas VAN BRUGGEN , Wyne P. LEE
摘要： The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.
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公开(公告)号：US20210338778A1
公开(公告)日：2021-11-04
申请号：US17162924
申请日：2021-01-29
申请人： Genentech, Inc.
发明人： Alexander R. ABBAS , Nico P. GHILARDI , Zora MODRUSAN , Dimitry M. DANILENKO , Frederic J. DE SAUVAGE , Wenjun OUYANG , Patricia A. VALDEZ , Yan ZHENG
摘要： The present invention relates to compositions and methods for treatment of microbial disorder by modulation of the host immune response. More particularly, the present invention relates to compositions that mediate an anti-microbial immune response, and methods of treating a microbial infection using such compositions.
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