公开(公告)号：US20240277859A1

公开(公告)日：2024-08-22

申请号：US18682046

申请日：2022-08-22

Applicant: Genentech, Inc.

Inventor： Rachel Hendricks ,  Matthew Henry Hutchinson ,  Mark Frederick Fedesco ,  Bejamin Phu Tran

IPC: A61K47/68 ,  C07K1/107 ,  C07K1/18

CPC classification number: A61K47/68 ,  C07K1/1077 ,  C07K1/18

Abstract: The present invention relates to a method of developing purification processes for antibody drug conjugates using cation-exchange chromatography in flow-through mode leveraging the purification conditions of the antibody intermediate without a change to the critical quality attributes (CQA) of the ADC.