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公开(公告)号：US20180282328A1
公开(公告)日：2018-10-04
申请号：US15942321
申请日：2018-03-30
申请人： Genentech, Inc.
发明人： Bryan Chan , Blake Daniels , Joy Drobnick , Lewis Gazzard , Timothy Heffron , Malcolm Huestis , Jun Liang , Sushant Malhotra , Rohan Mendonca , Naomi Rajapaksa , Michael Siu , Craig Stivala , John Tellis , Weiru Wang , BinQing Wei , Aihe Zhou , Matthew W. Cartwright , Emanuela Gancia , Graham Jones , Michael Lainchbury , Andrew Madin , Eileen Seward , David Favor , Kin Chiu Fong , Andrew Good , Yonghan Hu , Baihua Hu , Aijun Lu
IPC分类号： C07D471/04 , A61K45/06 , A61P35/00 , A61K31/444 , A61K31/4375 , A61K31/506 , C07D519/00 , A61K31/4545 , A61K31/4725 , A61K31/5383 , A61K31/496 , A61K31/5377 , A61K31/5025 , A61K31/551 , A61K31/55
CPC分类号： C07D471/04 , A61K31/4375 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/5025 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/55 , A61K31/551 , A61K45/06 , A61P35/00 , C07D519/00
摘要： Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.
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公开(公告)号：US10975095B2
公开(公告)日：2021-04-13
申请号：US16034207
申请日：2018-07-12
申请人： Genentech, Inc.
发明人： Snahel Patel , Gregory Hamilton , Guiling Zhao , Huifen Chen , Blake Daniels , Craig Stivala
IPC分类号： C07D498/04 , C07D487/04 , A61P25/16 , A61P25/28 , C07D235/12 , C07D471/04 , A61P17/06 , A61P21/00 , A61P19/02 , A61P1/00
摘要： The invention provides novel compounds having the general formula I: wherein R1, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.
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公开(公告)号：US20190127382A1
公开(公告)日：2019-05-02
申请号：US16175206
申请日：2018-10-30
申请人： Genentech, Inc.
发明人： Snahel Patel , Gregory Hamilton , Craig Stivala , Huifen Chen , Blake Daniels
IPC分类号： C07D487/04
摘要： The invention provides novel compounds having the general formula I: wherein R1, RB1, RB2, n, p, q, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.
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公开(公告)号：US11098058B2
公开(公告)日：2021-08-24
申请号：US16034207
申请日：2018-07-12
申请人： Genentech, Inc.
发明人： Snahel Patel , Gregory Hamilton , Guiling Zhao , Huifen Chen , Blake Daniels , Craig Stivala
IPC分类号： C07D498/04 , C07D487/04 , A61P25/16 , A61P25/28 , C07D235/12 , C07D471/04 , A61P17/06 , A61P21/00 , A61P19/02 , A61P1/00
摘要： The invention provides novel compounds having the general formula I: wherein R1, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.
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公开(公告)号：US11034692B1
公开(公告)日：2021-06-15
申请号：US16542129
申请日：2019-08-15
申请人： Genentech, Inc.
发明人： Bryan Chan , Blake Daniels , Joy Drobnick , Lewis Gazzard , Timothy Heffron , Malcolm Huestis , Jun Liang , Sushant Malhotra , Rohan Mendonca , Naomi Rajapaksa , Michael Siu , Craig Stivala , John Tellis , Weiru Wang , BinQing Wei , Aihe Zhou , Matthew W. Cartwright , Emanuela Gancia , Graham Jones , Michael Lainchbury , Andrew Madin , Eileen Seward , David Favor , Kin Chiu Fong , Andrew Good , Yonghan Hu , Baihua Hu , Aijun Lu
IPC分类号： C07D471/04 , A61K45/06 , A61P35/00 , A61K31/444 , A61K31/4375 , A61K31/506 , C07D519/00 , A61K31/4545 , A61K31/4725 , A61K31/5383 , A61K31/496 , A61K31/5377 , A61K31/5025 , A61K31/551 , A61K31/55
摘要： Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.
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公开(公告)号：US11834461B2
公开(公告)日：2023-12-05
申请号：US17147449
申请日：2021-01-12
申请人： Genentech, Inc.
发明人： Snahel Patel , Gregory Hamilton , Guiling Zhao , Huifen Chen , Blake Daniels , Craig Stivala
IPC分类号： C07D498/04 , C07D487/04 , A61P25/16 , A61P25/28 , A61P17/06 , A61P21/00 , A61P19/02 , A61P1/00 , C07D235/12 , C07D471/04
CPC分类号： C07D498/04 , A61P25/16 , A61P25/28 , C07D235/12 , C07D471/04 , C07D487/04 , A61P1/00 , A61P17/06 , A61P19/02 , A61P21/00
摘要： The invention provides novel compounds having the general formula I:
wherein R1, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.-
公开(公告)号：US11673892B2
公开(公告)日：2023-06-13
申请号：US16844952
申请日：2020-04-09
申请人： Genentech, Inc.
发明人： Huifen Chen , Gregory Hamilton , Snahel Patel , Guiling Zhao , Blake Daniels , Craig Stivala
IPC分类号： C07D487/04 , C07D519/00 , A61P25/28 , A61K31/4196 , A61P25/16
CPC分类号： C07D487/04 , A61P25/28 , C07D519/00 , C07B2200/05
摘要： The invention provides novel compounds having the general formula I:
or pharmaceutically acceptable salts thereof, wherein
RA, RB1, RB2, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.-
公开(公告)号：US20230002391A1
公开(公告)日：2023-01-05
申请号：US17340082
申请日：2021-06-06
申请人： Genentech, Inc.
发明人： Snahel Patel , Gregory Hamilton , Craig Stivala , Huifen Chen , Blake Daniels
IPC分类号： C07D487/04 , C07D231/54 , C07D249/16 , A61P25/00
摘要： The invention provides novel compounds having the general formula I: wherein R1, RB1, RB2, n, p, q, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.
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公开(公告)号：US11072617B2
公开(公告)日：2021-07-27
申请号：US16175206
申请日：2018-10-30
申请人： Genentech, Inc.
发明人： Snahel Patel , Gregory Hamilton , Craig Stivala , Huifen Chen , Blake Daniels
IPC分类号： C07D487/04 , C07D231/54 , C07D249/16 , A61P25/00
摘要： The invention provides novel compounds having the general formula I: wherein R1, RB1, RB2, n, p, q, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.
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公开(公告)号：US10407424B2
公开(公告)日：2019-09-10
申请号：US15942321
申请日：2018-03-30
申请人： Genentech, Inc.
发明人： Bryan Chan , Naomi Rajapaksa , Michael Siu , Craig Stivala , John Tellis , Weiru Wang , BinQing Wei , Aihe Zhou , Matthew W. Cartwright , Emanuela Gancia , Graham Jones , Blake Daniels , Michael Lainchbury , Andrew Madin , Eileen Seward , David Favor , Kin Chiu Fong , Andrew Good , Yonghan Hu , Baihua Hu , Aijun Lu , Joy Drobnick , Lewis Gazzard , Timothy Heffron , Malcolm Huestis , Jun Liang , Sushant Malhotra , Rohan Mendonca
IPC分类号： C07D471/04 , A61K31/55 , A61P35/00 , A61K31/444 , A61K31/4375 , A61K31/506 , C07D519/00 , A61K31/4545 , A61K31/4725 , A61K31/5383 , A61K31/496 , A61K31/5377 , A61K31/5025 , A61K31/551 , A61K45/06
摘要： Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.
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