公开(公告)号：US20230002345A1

公开(公告)日：2023-01-05

申请号：US16642824

申请日：2019-08-15

Applicant: Genentech, Inc.

Inventor： Aijun LU ,  Sushant Malhotra ,  Alan G. Olivero ,  Cheng Shao ,  Yamin Zhang ,  Steven Do

IPC: C07D401/04 ,  C07D403/04 ,  C07D239/94 ,  C07D405/04 ,  C07D403/12 ,  C07D403/14 ,  C07D401/14 ,  C07D413/12 ,  C07D471/04

Abstract: Provided are fused ring compounds of Formula (I), Formula (II), or Formula (III), as further detailed herein, which are used for the inhibition of Ras proteins, as well as compositions comprising these compounds and methods treatment by their administration.

公开(公告)号：US11760744B2

公开(公告)日：2023-09-19

申请号：US16642824

申请日：2019-08-15

Applicant: Genentech, Inc.

Inventor： Aijun Lu ,  Sushant Malhotra ,  Alan G. Olivero ,  Cheng Shao ,  Yamin Zhang ,  Steven Do

IPC: C07D401/04 ,  C07D239/94 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D413/12 ,  C07D471/04

CPC classification number: C07D401/04 ,  C07D239/94 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D413/12 ,  C07D471/04

Abstract: Provided are fused ring compounds of Formula (I), Formula (II), or Formula (III), as further detailed herein, which are used for the inhibition of Ras proteins, as well as compositions comprising these compounds and methods treatment by their administration.