公开(公告)号：US20250073345A1

公开(公告)日：2025-03-06

申请号：US18784398

申请日：2024-07-25

Applicant: Genentech, Inc.

Inventor： Daniel P. SUTHERLIN ,  Donglu ZHANG ,  Summer A. BAKER DOCKERY ,  Peter Scott DRAGOVICH

IPC: A61K47/68

Abstract: The subject matter described herein is directed to molecules referred to herein as chemical inducers of degradation (CIDEs) and antibody-conjugated CIDEs (Ab-CIDEs), wherein the Ab-CIDEs comprise an antibody covalently bound to the CIDE through a linker, wherein the CIDE can be further covalently bound to a phosphate moiety, and to the uses of the molecules in treating diseases and conditions where targeted protein degradation is beneficial.

公开(公告)号：US20200085965A1

公开(公告)日：2020-03-19

申请号：US16689286

申请日：2019-11-20

Applicant: GENENTECH, INC.

Inventor： Peter DRAGOVICH ,  Zhonghua PEI ,  Thomas PILLOW ,  Jack SADOWSKY ,  Vishal VERMA ,  Donglu ZHANG

IPC: A61K47/68 ,  A61K31/5517 ,  A61P35/00

Abstract: The invention relates generally to pyrrolobenzodiazepine monomer and dimer prodrugs having a glutathione-activated disulfide prodrug moiety, a DT-diaphorase-activated quinone prodrug moiety or a reactive oxygen species-activated aryl boronic acid or aryl boronic ester prodrug moiety. The invention further relates to pyrrolobenzodiazepine prodrug dimer-antibody conjugates.

公开(公告)号：US20250064968A1

公开(公告)日：2025-02-27

申请号：US18784386

申请日：2024-07-25

Applicant: Genentech, Inc.

Inventor： Daniel P. SUTHERLIN ,  Donglu ZHANG ,  Summer A. BAKER DOCKERY ,  Peter Scott DRAGOVICH

IPC: A61K47/68

Abstract: The subject matter described herein relates generally to hydrolysable maleimide-containing molecules that are useful as linkers to covalently bind chemical inducers of degradation to antibodies and to the conjugates produced therefrom and their uses to treat conditions, and to the uses of the conjugates in treating diseases and conditions where targeted protein degradation is beneficial.

公开(公告)号：US20230330249A1

公开(公告)日：2023-10-19

申请号：US18156744

申请日：2023-01-19

Applicant: Genentech, Inc.

Inventor： Peter Scott DRAGOVICH ,  Summer A. BAKER DOCKREY ,  Thomas Harden PILLOW ,  Donglu ZHANG

IPC: A61K47/68 ,  A61P35/00

CPC classification number: A61K47/6811 ,  A61P35/00

Abstract: The subject matter described herein is directed to antibody-CIDE conjugates (Ab-CIDEs) that target BRM for degradation, to pharmaceutical compositions containing them, and to their use in treating diseases and conditions where BRM degradation is beneficial.

公开(公告)号：US20190175749A1

公开(公告)日：2019-06-13

申请号：US16271549

申请日：2019-02-08

Applicant: GENENTECH, INC.

Inventor： Peter DRAGOVICH ,  Zhonghua PEI ,  Thomas PILLOW ,  Jack SADOWSKY ,  Vishal VERMA ,  Donglu ZHANG

IPC: A61K47/68 ,  A61P35/00 ,  A61K31/5517

Abstract: The invention relates generally to pyrrolobenzodiazepine monomer and dimer prodrugs having a glutathione-activated disulfide prodrug moiety, a DT-diaphorase-activated quinone prodrug moiety or a reactive oxygen species-activated aryl boronic acid or aryl boronic ester prodrug moiety. The invention further relates to pyrrolobenzodiazepine prodrug dimer-antibody conjugates.