公开(公告)号：US20250073345A1

公开(公告)日：2025-03-06

申请号：US18784398

申请日：2024-07-25

Applicant: Genentech, Inc.

Inventor： Daniel P. SUTHERLIN ,  Donglu ZHANG ,  Summer A. BAKER DOCKERY ,  Peter Scott DRAGOVICH

IPC: A61K47/68

Abstract: The subject matter described herein is directed to molecules referred to herein as chemical inducers of degradation (CIDEs) and antibody-conjugated CIDEs (Ab-CIDEs), wherein the Ab-CIDEs comprise an antibody covalently bound to the CIDE through a linker, wherein the CIDE can be further covalently bound to a phosphate moiety, and to the uses of the molecules in treating diseases and conditions where targeted protein degradation is beneficial.

公开(公告)号：US20250064968A1

公开(公告)日：2025-02-27

申请号：US18784386

申请日：2024-07-25

Applicant: Genentech, Inc.

Inventor： Daniel P. SUTHERLIN ,  Donglu ZHANG ,  Summer A. BAKER DOCKERY ,  Peter Scott DRAGOVICH

IPC: A61K47/68

Abstract: The subject matter described herein relates generally to hydrolysable maleimide-containing molecules that are useful as linkers to covalently bind chemical inducers of degradation to antibodies and to the conjugates produced therefrom and their uses to treat conditions, and to the uses of the conjugates in treating diseases and conditions where targeted protein degradation is beneficial.