公开(公告)号：US20250073345A1

公开(公告)日：2025-03-06

申请号：US18784398

申请日：2024-07-25

Applicant: Genentech, Inc.

Inventor： Daniel P. SUTHERLIN ,  Donglu ZHANG ,  Summer A. BAKER DOCKERY ,  Peter Scott DRAGOVICH

IPC: A61K47/68

Abstract: The subject matter described herein is directed to molecules referred to herein as chemical inducers of degradation (CIDEs) and antibody-conjugated CIDEs (Ab-CIDEs), wherein the Ab-CIDEs comprise an antibody covalently bound to the CIDE through a linker, wherein the CIDE can be further covalently bound to a phosphate moiety, and to the uses of the molecules in treating diseases and conditions where targeted protein degradation is beneficial.

公开(公告)号：US20240228463A1

公开(公告)日：2024-07-11

申请号：US18584311

申请日：2024-02-22

Applicant: Genentech, Inc.

Inventor： Marc KSCHONSAK ,  Steven John MCKERRALL ,  Daniel Fred ORTWINE ,  Jian Mehr-Dean PAYANDEH ,  Benjamin Douglas SELLERS ,  John C. TELLIS ,  Matthew VOLGRAF ,  Philippe BERGERON ,  Claudio CIFERRI ,  Peter Scott DRAGOVICH

IPC: C07D401/12 ,  A61K31/18 ,  A61P25/04 ,  C07C311/51 ,  C07D211/96 ,  C07D277/44 ,  C07D277/82 ,  C07D295/26 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

CPC classification number: C07D401/12 ,  A61K31/18 ,  A61P25/04 ,  C07C311/51 ,  C07D211/96 ,  C07D277/44 ,  C07D277/82 ,  C07D295/26 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

Abstract: The invention provides compounds of formulae I, II, IIa, and III:




and pharmaceutically acceptable salts thereof, as well as compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US20250064968A1

公开(公告)日：2025-02-27

申请号：US18784386

申请日：2024-07-25

Applicant: Genentech, Inc.

Inventor： Daniel P. SUTHERLIN ,  Donglu ZHANG ,  Summer A. BAKER DOCKERY ,  Peter Scott DRAGOVICH

IPC: A61K47/68

Abstract: The subject matter described herein relates generally to hydrolysable maleimide-containing molecules that are useful as linkers to covalently bind chemical inducers of degradation to antibodies and to the conjugates produced therefrom and their uses to treat conditions, and to the uses of the conjugates in treating diseases and conditions where targeted protein degradation is beneficial.

公开(公告)号：US20230330249A1

公开(公告)日：2023-10-19

申请号：US18156744

申请日：2023-01-19

Applicant: Genentech, Inc.

Inventor： Peter Scott DRAGOVICH ,  Summer A. BAKER DOCKREY ,  Thomas Harden PILLOW ,  Donglu ZHANG

IPC: A61K47/68 ,  A61P35/00

CPC classification number: A61K47/6811 ,  A61P35/00

Abstract: The subject matter described herein is directed to antibody-CIDE conjugates (Ab-CIDEs) that target BRM for degradation, to pharmaceutical compositions containing them, and to their use in treating diseases and conditions where BRM degradation is beneficial.