公开(公告)号：US11155777B2

公开(公告)日：2021-10-26

申请号：US16728733

申请日：2019-12-27

Applicant: Genentech, Inc.

Inventor： Ekta Mahajan ,  Kelsey Dent ,  Edward Chan ,  Terry Hudson ,  Neria Daniel

IPC: C12M3/00 ,  C12M1/00 ,  C12M1/06 ,  B01F7/16 ,  B01F15/00 ,  B01F13/08 ,  C12M1/02 ,  C12M1/36 ,  B01F15/06

Abstract: Described herein are bioreactor support structures configured to be used with containers having different designs, and methods for making and using such bioreactors. The support structures described herein may include two or more agitator motors and control systems or an adjustable-position agitator motor, a removable spacer and/or lid, multiple configurations for ports and probes, and multiple exhaust filter heating blankets. Also described herein are methods of manufacturing a multi-agitator motor or adjustable-position agitator motor bioreactor, as well as methods of modifying an existing support structure to be used with a container not originally designed to be used with the existing support structure, and methods for operating these bioreactors.

公开(公告)号：US10940401B2

公开(公告)日：2021-03-09

申请号：US15920237

申请日：2018-03-13

Applicant: Genentech, Inc.

Inventor： Ekta Mahajan ,  Joanna So ,  Jay Werber

IPC: B01D15/20 ,  B01J49/60 ,  B01D15/38 ,  C07K1/18 ,  C07K1/22

Abstract: The present invention provides methods for cleaning or regenerating a chromatography materiel for reuse. The methods of the invention can be used for cleaning or regenerating chromatography columns for reuse in the large-scale manufacture of multiple polypeptide products.

公开(公告)号：US10563161B2

公开(公告)日：2020-02-18

申请号：US15071109

申请日：2016-03-15

Applicant: Genentech, Inc.

Inventor： Ekta Mahajan ,  Kelsey Dent ,  Edward Chan ,  Terry Hudson ,  Neria Daniel

IPC: C12M3/00 ,  C12M1/00 ,  C12M1/06 ,  C12M1/02 ,  C12M1/36 ,  B01F7/16 ,  B01F13/08 ,  B01F15/00 ,  B01F15/06

Abstract: Described herein are bioreactor support structures configured to be used with containers having different designs, and methods for making and using such bioreactors. The support structures described herein may include two or more agitator motors and control systems or an adjustable-position agitator motor, a removable spacer and/or lid, multiple configurations for ports and probes, and multiple exhaust filter heating blankets. Also described herein are methods of manufacturing a multi-agitator motor or adjustable-position agitator motor bioreactor, as well as methods of modifying an existing support structure to be used with a container not originally designed to be used with the existing support structure, and methods for operating these bioreactors.