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公开(公告)号:US20220024945A1
公开(公告)日:2022-01-27
申请号:US17449398
申请日:2021-09-29
Applicant: Genentech, Inc.
Inventor: Mark ZAK , F. Anthony ROMERO , Yun-Xing CHENG , Wei LI
IPC: C07D498/04 , C07D487/04 , A61P11/00
Abstract: Compounds and salts thereof that are useful as JAK kinase inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.
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2.
公开(公告)号:US20230242530A1
公开(公告)日:2023-08-03
申请号:US18297546
申请日:2023-04-07
Applicant: Genentech, Inc.
Inventor: Simon Charles GOODACRE , Mark ZAK , F. Anthony ROMERO , Yun-Xing CHENG , Limin CHENG , Rongbao HUA
IPC: C07D471/04 , A61P11/06 , C07D519/00
CPC classification number: C07D471/04 , A61P11/06 , C07D519/00
Abstract: Compounds of Formula (I) and (II), or a stereoisomer, tautomer, solvate, prodrug or salt thereof, and methods of use as Janus kinase inhibitors are described herein.
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3.
公开(公告)号:US20200270248A1
公开(公告)日:2020-08-27
申请号:US16870602
申请日:2020-05-08
Applicant: Genentech, Inc.
Inventor: Simon Charles GOODACRE , Mark ZAK , F. Anthony ROMERO , Yun-Xing CHENG , Limin CHENG , Rongbao HUA
IPC: C07D471/04 , A61P11/06 , C07D519/00
Abstract: Compounds of Formula (I) and (II), or a stereoisomer, tautomer, solvate, prodrug or salt thereof, and methods of use as Janus kinase inhibitors are described herein.
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公开(公告)号:US20200002346A1
公开(公告)日:2020-01-02
申请号:US16561447
申请日:2019-09-05
Applicant: Genentech, Inc.
Inventor: Mark ZAK , F. Anthony ROMERO , Po-wai YUEN , Emily J. HANAN
IPC: C07D487/04 , C07D471/04 , C07D491/048 , C07D498/04 , C07D513/04
Abstract: Compounds of Formula I and methods of use as Janus kinase inhibitors are described herein.
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公开(公告)号:US20200062779A1
公开(公告)日:2020-02-27
申请号:US16668714
申请日:2019-10-30
Applicant: Genentech, Inc.
Inventor: Mark ZAK , F. Anthony ROMERO , Yun-Xing CHENG , Wei LI
IPC: C07D498/04 , A61P11/00 , C07D487/04
Abstract: Compounds and salts thereof that are useful as JAK kinase inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.
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6.
公开(公告)号:US20190202822A1
公开(公告)日:2019-07-04
申请号:US16293129
申请日:2019-03-05
Applicant: Genentech, Inc.
Inventor: Simon Charles GOODACRE , Mark ZAK , F. Anthony ROMERO , Yun-Xing CHENG , Limin CHENG , Rongbao HUA
IPC: C07D471/04 , C07D519/00 , A61P11/06
CPC classification number: C07D471/04 , A61P11/06 , C07D519/00
Abstract: Compounds of Formula (I) and (II), or a stereoisomer, tautomer, solvate, prodrug or salt thereof, and methods of use as Janus kinase inhibitors are described herein.
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公开(公告)号:US20180334465A1
公开(公告)日:2018-11-22
申请号:US15984728
申请日:2018-05-21
Applicant: Genentech, Inc.
Inventor: Mark ZAK , F. Anthony ROMERO , Yun-Xing CHENG , Wei LI
IPC: C07D498/04
CPC classification number: C07D498/04 , A61P11/00 , C07D487/04
Abstract: Compounds and salts thereof that are useful as JAK kinase inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.
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公开(公告)号:US20210179626A1
公开(公告)日:2021-06-17
申请号:US17174733
申请日:2021-02-12
Applicant: Genentech, Inc.
Inventor: Mark ZAK , F. Anthony ROMERO , Po-wai YUEN , Emily J. HANAN
IPC: C07D487/04 , C07D471/04 , C07D491/048 , C07D498/04 , C07D513/04
Abstract: Compounds of Formula I and methods of use as Janus kinase inhibitors are described herein.
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公开(公告)号:US20190240227A1
公开(公告)日:2019-08-08
申请号:US16387187
申请日:2019-04-17
Applicant: Genentech, Inc.
Inventor: Mark ZAK , F. Anthony ROMERO , Yun-Xing CHENG
IPC: A61K31/519 , A61P11/06 , C07D487/04 , A61P29/00
CPC classification number: A61K31/519 , A61P11/06 , A61P29/00 , C07D487/04
Abstract: Compounds and salts thereof that are useful as JAK kinase inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.
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公开(公告)号:US20180333416A1
公开(公告)日:2018-11-22
申请号:US15984747
申请日:2018-05-21
Applicant: Genentech, Inc.
Inventor: Mark ZAK , F. Anthony ROMERO , Yun-Xing CHENG
IPC: A61K31/519 , A61P11/06
CPC classification number: A61K31/519 , A61P11/06 , A61P29/00 , C07D487/04
Abstract: Compounds and salts thereof that are useful as JAK kinse inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.
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