公开(公告)号：US20230242530A1

公开(公告)日：2023-08-03

申请号：US18297546

申请日：2023-04-07

Applicant: Genentech, Inc.

Inventor： Simon Charles GOODACRE ,  Mark ZAK ,  F. Anthony ROMERO ,  Yun-Xing CHENG ,  Limin CHENG ,  Rongbao HUA

IPC: C07D471/04 ,  A61P11/06 ,  C07D519/00

CPC classification number: C07D471/04 ,  A61P11/06 ,  C07D519/00

Abstract: Compounds of Formula (I) and (II), or a stereoisomer, tautomer, solvate, prodrug or salt thereof, and methods of use as Janus kinase inhibitors are described herein.

公开(公告)号：US20230025834A1

公开(公告)日：2023-01-26

申请号：US17447361

申请日：2021-09-10

Applicant: Genentech, Inc.

Inventor： Guosheng WU ,  Emily J. HANAN ,  Marie-Gabrielle BRAUN ,  Sharada S. LABADIE ,  Keira GARLAND ,  Richard M. PASTOR ,  Paul Anthony GIBBONS ,  Yuhong FU ,  Yun-Xing CHENG

IPC: C07K7/56

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of lipoprotein signal peptidase II (LspA), a key protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

公开(公告)号：US20220024945A1

公开(公告)日：2022-01-27

申请号：US17449398

申请日：2021-09-29

Applicant: Genentech, Inc.

Inventor： Mark ZAK ,  F. Anthony ROMERO ,  Yun-Xing CHENG ,  Wei LI

IPC: C07D498/04 ,  C07D487/04 ,  A61P11/00

Abstract: Compounds and salts thereof that are useful as JAK kinase inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

公开(公告)号：US20160237086A1

公开(公告)日：2016-08-18

申请号：US15139164

申请日：2016-04-26

Applicant: Genentech, Inc.

Inventor： Mark Edward ZAK ,  Nicholas Charles RAY ,  Simon Charles GOODACRE ,  Rohan MENDONCA ,  Terry KELLAR ,  Yun-Xing CHENG ,  Wei LI ,  Po-Wei YUEN

IPC: C07D471/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  A61K31/519 ,  C07D487/04 ,  C07D519/00

Abstract: Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.

Abstract translation: 本文描述了式（00A）的化合物和用作Janus激酶抑制剂的方法。

公开(公告)号：US20230206644A1

公开(公告)日：2023-06-29

申请号：US18176389

申请日：2023-02-28

Applicant: Genentech, Inc.

Inventor： Mark ZAK ,  Paul GIBBONS ,  Yun-Xing CHENG ,  Simon Charles GOODACRE

IPC: G06V20/52 ,  G06M11/00 ,  G08G1/005 ,  G08G1/04 ,  H04N7/18 ,  G06F3/147

CPC classification number: G06V20/53 ,  G06M11/00 ,  G08G1/005 ,  G08G1/04 ,  H04N7/188 ,  G06F3/147 ,  H04N7/181 ,  G09G2380/06

Abstract: Compounds and salts thereof that are useful as JAK kinase inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

公开(公告)号：US20190240227A1

公开(公告)日：2019-08-08

申请号：US16387187

申请日：2019-04-17

Applicant: Genentech, Inc.

Inventor： Mark ZAK ,  F. Anthony ROMERO ,  Yun-Xing CHENG

IPC: A61K31/519 ,  A61P11/06 ,  C07D487/04 ,  A61P29/00

CPC classification number: A61K31/519 ,  A61P11/06 ,  A61P29/00 ,  C07D487/04

Abstract: Compounds and salts thereof that are useful as JAK kinase inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

公开(公告)号：US20180333416A1

公开(公告)日：2018-11-22

申请号：US15984747

申请日：2018-05-21

Applicant: Genentech, Inc.

Inventor： Mark ZAK ,  F. Anthony ROMERO ,  Yun-Xing CHENG

IPC: A61K31/519 ,  A61P11/06

CPC classification number: A61K31/519 ,  A61P11/06 ,  A61P29/00 ,  C07D487/04

Abstract: Compounds and salts thereof that are useful as JAK kinse inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

公开(公告)号：US20240383915A1

公开(公告)日：2024-11-21

申请号：US18554438

申请日：2022-04-06

Applicant: Genentech, Inc.

Inventor： Lewis J. GAZZARD ,  Samantha Alyson GREEN ,  Elizabeth H. KELLEY ,  Matthew Leo LANDRY ,  Sushant MALHOTRA ,  Benjamin David RAVETZ ,  Michael SIU ,  Jack Alexander TERRETT ,  BinQing WEI ,  Steven DO ,  Yun-Xing CHENG ,  Limin CHENG ,  Jianfeng XIN ,  Mingtao HE ,  Guosheng WU ,  Yinlei SUN ,  Cheng SHAO ,  Aijun LU ,  Yulai ZHANG

IPC: C07D498/04 ,  A61K31/553 ,  A61K45/06 ,  C07D519/00

Abstract: Provided herein are acyclic oxazepinyl compounds useful in the treatment on cancers.

公开(公告)号：US20200339604A1

公开(公告)日：2020-10-29

申请号：US16927436

申请日：2020-07-13

Applicant: Genentech, Inc.

Inventor： Mark ZAK ,  Paul GIBBONS ,  Yun-Xing CHENG ,  Simon Charles GOODACRE

IPC: C07D519/00 ,  C07D487/04 ,  A61P11/06

Abstract: Compounds and salts thereof that are useful as JAK kinse inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

公开(公告)号：US20200270248A1

公开(公告)日：2020-08-27

申请号：US16870602

申请日：2020-05-08

Applicant: Genentech, Inc.

Inventor： Simon Charles GOODACRE ,  Mark ZAK ,  F. Anthony ROMERO ,  Yun-Xing CHENG ,  Limin CHENG ,  Rongbao HUA

IPC: C07D471/04 ,  A61P11/06 ,  C07D519/00

Abstract: Compounds of Formula (I) and (II), or a stereoisomer, tautomer, solvate, prodrug or salt thereof, and methods of use as Janus kinase inhibitors are described herein.