公开(公告)号：US20220056078A1

公开(公告)日：2022-02-24

申请号：US17517103

申请日：2021-11-02

Applicant: Genentech, Inc.

Inventor： Filip PETRONIJEVIC ,  Ngiap-Kie LIM ,  Nicholas WONG ,  Allen HONG ,  Haiyun HOU ,  Xin LINGHU ,  Francis GOSSELIN

IPC: C07K7/64 ,  C07K1/06

Abstract: Methods for making an arylomycin ring of formula t or salts or solvates thereof, wherein R, R1, R2, R3, R4, R5, R6, R7, R8, R9, R5, R10 and Pg1 are as defined herein.

公开(公告)号：US20250059147A1

公开(公告)日：2025-02-20

申请号：US18816550

申请日：2024-08-27

Applicant: Genentech, Inc. ,  Hoffmann-La Roche Inc.

Inventor： Allen Yu HONG ,  Jacob C. TIMMERMAN ,  Francis GOSSELIN ,  Katarzyna Aleksandra PIECHOWICZ ,  Filip PETRONIJEVIC ,  Kurt PUENTENER ,  Anna-Lena GLASS ,  Etienne TRACHSEL

IPC: C07D307/24 ,  B01J31/20 ,  B01J31/22 ,  B01J31/24 ,  C07D307/12 ,  C07D307/14 ,  C07D307/16

Abstract: Provided are phenyltetrahydrofuran compounds that are useful as intermediates in the preparation of pharmaceutical compounds and further provided are processes for the preparation of phenyltetrahydrofuran compounds.

公开(公告)号：US20200255476A1

公开(公告)日：2020-08-13

申请号：US16581116

申请日：2019-09-24

Applicant: Genentech, Inc.

Inventor： Filip PETRONIJEVIC ,  Ngiap-Kie LIM ,  Nicholas WONG ,  Allen HONG ,  Haiyun HOU ,  Xin LINGHU ,  Francis GOSSELIN

IPC: C07K7/64 ,  C07K1/06

Abstract: Methods for making an arylomycin ring of formula t or salts or solvates thereof, wherein R, R1, R2, R3, R4, R5, R6, R7, R8, R9, R5, R10 and Pg1 are as defined herein.