公开(公告)号：US20200255476A1

公开(公告)日：2020-08-13

申请号：US16581116

申请日：2019-09-24

Applicant: Genentech, Inc.

Inventor： Filip PETRONIJEVIC ,  Ngiap-Kie LIM ,  Nicholas WONG ,  Allen HONG ,  Haiyun HOU ,  Xin LINGHU ,  Francis GOSSELIN

IPC: C07K7/64 ,  C07K1/06

Abstract: Methods for making an arylomycin ring of formula t or salts or solvates thereof, wherein R, R1, R2, R3, R4, R5, R6, R7, R8, R9, R5, R10 and Pg1 are as defined herein.

公开(公告)号：US20240294464A1

公开(公告)日：2024-09-05

申请号：US18642526

申请日：2024-04-22

Applicant: Genentech, Inc.

Inventor： Nicholas WONG ,  Francis GOSSELIN

IPC: C07C229/34 ,  A61K51/08 ,  A61K51/10 ,  C07C57/15 ,  C07C227/18 ,  C07C227/40 ,  C07D239/557 ,  C07D319/12 ,  C07F5/06

CPC classification number: C07C229/34 ,  A61K51/088 ,  A61K51/1096 ,  C07C57/15 ,  C07C227/18 ,  C07C227/40 ,  C07D239/557 ,  C07D319/12 ,  C07F5/069 ,  C07B2200/05

Abstract: Improved methods of synthesis of a restrained complexing agent are described herein. Compounds, including salts and solvates thereof, and compositions relevant to the improved methods are also described.

公开(公告)号：US20240034739A1

公开(公告)日：2024-02-01

申请号：US18479596

申请日：2023-10-02

Applicant: Genentech, Inc. ,  Hoffmann-La Roche Inc.

Inventor： Allen Yu HONG ,  Nicholas WONG ,  Sean M. KELLY ,  Lauren Elizabeth SIROIS ,  Sara SCHWEGLER ,  Xin LINGHU ,  Francis GOSSELIN ,  Katarzyna Aleksandra PIECHOWICZ ,  Carmela MOLINARO ,  Dennis WETZL

IPC: C07D487/04 ,  C12P7/62 ,  C07D207/273

CPC classification number: C07D487/04 ,  C12P7/62 ,  C07D207/273

Abstract: Processes are provided herein for the preparation of a bicyclic ketone compound of formula (I), or a stereoisomer thereof:






or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and n are as defined herein; and compounds prepared by these processes.

公开(公告)号：US20220056078A1

公开(公告)日：2022-02-24

申请号：US17517103

申请日：2021-11-02

Applicant: Genentech, Inc.

Inventor： Filip PETRONIJEVIC ,  Ngiap-Kie LIM ,  Nicholas WONG ,  Allen HONG ,  Haiyun HOU ,  Xin LINGHU ,  Francis GOSSELIN

IPC: C07K7/64 ,  C07K1/06

Abstract: Methods for making an arylomycin ring of formula t or salts or solvates thereof, wherein R, R1, R2, R3, R4, R5, R6, R7, R8, R9, R5, R10 and Pg1 are as defined herein.