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公开(公告)号：US09040706B2
公开(公告)日：2015-05-26
申请号：US14088110
申请日：2013-11-22
Applicant: Genentech, Inc.
Inventor： Frederick Cohen , Vickie Hsiao-Wei Tsui , Cuong Ly , John A. Flygare
IPC: C07D277/20 , C07D453/02 , C07D471/14 , C07D471/04 , C07D417/04 , C07D417/14
CPC classification number: C07D471/04 , C07D417/04 , C07D417/14
Abstract: The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, Q, X1, X2, Y, R1, R2, R3, R4, R4′, R5, R6 and R6′ are as described herein.
Abstract translation: 本发明提供了可用作治疗恶性肿瘤的治疗剂的新的IAP抑制剂，其中化合物具有通式I：其中A，Q，X 1，X 2，Y，R 1，R 2，R 3，R 4，R 4'，R 5，R 6 和R6'如本文所述。
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公开(公告)号：US20190224269A1
公开(公告)日：2019-07-25
申请号：US16372940
申请日：2019-04-02
Applicant: GENENTECH, INC.
Inventor： Frederick Cohen , Lewis J. Gazzard , Vickie Hsiao-Wei Tsui , John A. Flygare
Abstract: Novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies and have the general formula I: wherein R1,R2,R3,R4,R5 and R6 are as described herein.
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公开(公告)号：US09868720B2
公开(公告)日：2018-01-16
申请号：US14928034
申请日：2015-10-30
Applicant: Genentech, Inc.
Inventor： Frederick Cohen , Snahel Patel
IPC: A61K31/506 , C07D401/14 , C07D405/14 , C07D403/14 , C07D471/04 , C07D493/08 , A61K31/5377 , A61K31/5386 , A61K31/553 , A61K35/30 , C07D409/14 , C07D413/14 , C07D487/04 , C07D491/08 , C07D491/107 , C07D498/08
CPC classification number: C07D401/14 , A61K31/506 , A61K31/5377 , A61K31/5386 , A61K31/553 , A61K35/30 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/08 , C07D491/107 , C07D493/08 , C07D498/08
Abstract: The present invention provides for pyrimidine compounds of Formula I-I and embodiments thereof In Formula I-I in which R1, R2, R3, R4, R5, R6, m, n and the “het” ring are as described herein. Also provided are pharmaceutical compositions comprising compounds of Formula I and methods of using such compounds and compositions.
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公开(公告)号：US09586991B2
公开(公告)日：2017-03-07
申请号：US14974140
申请日：2015-12-18
Applicant: GENENTECH, INC.
Inventor： Frederick Cohen , Lewis J. Gazzard , Vickie Hsiao-Wei Tsui , John A. Flygare
CPC classification number: A61K38/06 , A61K38/00 , A61K45/06 , C07K5/08 , C07K5/0804 , C07K5/0806 , C07K5/0812 , C07K5/0815
Abstract: Novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies and have the general formula I: wherein R1, R2, R3, R4, R5 and R6 are as described herein.
Abstract translation: 可用作治疗恶性肿瘤的治疗剂并具有通式I的IAP的新型抑制剂：其中R 1，R 2，R 3，R 4，R 5和R 6如本文所述。
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公开(公告)号：US08716236B2
公开(公告)日：2014-05-06
申请号：US13733244
申请日：2013-01-03
Applicant: Genentech, Inc.
Inventor： Frederick Cohen , Lewis J. Gazzard , Vickie Hsiao-Wei Tsui , John A. Flygare
IPC: A61K38/00 , C07D211/60 , C07D307/14 , C07D307/52 , C07D319/22
CPC classification number: A61K38/06 , A61K38/00 , A61K45/06 , C07K5/08 , C07K5/0804 , C07K5/0806 , C07K5/0812 , C07K5/0815
Abstract: Novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies and have the general formula I: wherein R1, R2, R3, R4, R5 and R6 are as described herein.
Abstract translation: 可用作治疗恶性肿瘤的治疗剂的具有通式I的IAP的新型抑制剂：其中R1，R2，R3，R4，R5和R6如本文所述。
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Patent Agency Ranking
公开(公告)号：US20150080367A1
公开(公告)日：2015-03-19
申请号：US14550528
申请日：2014-11-21
Applicant: Genentech, Inc.
Inventor： Frederick Cohen , Malcolm Huestis , Cuong Ly , Snahel Patel , Michael Siu , Xianrui Zhao
IPC: C07D401/14 , C07D491/107 , C07D487/08 , C07D405/14
CPC classification number: C07D401/14 , C07D401/12 , C07D405/14 , C07D487/08 , C07D491/107
Abstract: The present invention provides for compounds of Formula I and various embodiments thereof, and compositions comprising compounds of Formula I and various embodiments thereof. In compounds of Formula I, the groups R1, R2, R3, R4, R5, R6, m, n and the C-linked Ring have the meaning as described herein. The present invention also provides for methods of using compounds of Formula I and compositions comprising compounds of Formula I as DLK inhibitors and for treating neurodegeneration diseases and disorders.
Abstract translation: 本发明提供式I化合物及其各种实施方案，以及包含式I化合物及其各种实施方案的组合物。 在式I化合物中，基团R 1，R 2，R 3，R 4，R 5，R 6，m，n和C连接的环具有如本文所述的含义。 本发明还提供使用式I化合物的方法和包含式I化合物的组合物作为DLK抑制剂并用于治疗神经变性疾病和病症。
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公开(公告)号：US09399636B2
公开(公告)日：2016-07-26
申请号：US14550528
申请日：2014-11-21
Applicant: Genentech, Inc.
Inventor： Frederick Cohen , Malcolm Huestis , Cuong Ly , Snahel Patel , Michael Siu , Xianrui Zhao
IPC: C07D401/14 , C07D401/12 , C07D405/14 , C07D487/08 , C07D491/107
CPC classification number: C07D401/14 , C07D401/12 , C07D405/14 , C07D487/08 , C07D491/107
Abstract: The present invention provides for compounds of Formula I and various embodiments thereof, and compositions comprising compounds of Formula I and various embodiments thereof. In compounds of Formula I, the groups R1, R2, R3, R4, R5, R6, m, n and the C-linked Ring have the meaning as described herein. The present invention also provides for methods of using compounds of Formula I and compositions comprising compounds of Formula I as DLK inhibitors and for treating neurodegeneration diseases and disorders.
Abstract translation: 本发明提供式I化合物及其各种实施方案，以及包含式I化合物及其各种实施方案的组合物。 在式I化合物中，基团R 1，R 2，R 3，R 4，R 5，R 6，m，n和C连接的环具有如本文所述的含义。 本发明还提供使用式I化合物的方法和包含式I化合物的组合物作为DLK抑制剂并用于治疗神经变性疾病和病症。
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公开(公告)号：US20160046608A1
公开(公告)日：2016-02-18
申请号：US14928034
申请日：2015-10-30
Applicant: Genentech, Inc.
Inventor： Frederick Cohen , Snahel Patel
IPC: C07D401/14 , C07D409/14 , A61K31/5377 , C07D491/08 , C07D413/14 , A61K35/30 , A61K31/5386 , C07D405/14 , C07D471/04 , A61K31/553 , C07D487/04 , C07D491/107 , A61K31/506 , C07D498/08
CPC classification number: C07D401/14 , A61K31/506 , A61K31/5377 , A61K31/5386 , A61K31/553 , A61K35/30 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/08 , C07D491/107 , C07D493/08 , C07D498/08
Abstract: The present invention provides for pyrimidine compounds of Formula I-I and embodiments thereof In Formula I-I in which R1, R2, R3, R4, R5, R6, m, n and the “het” ring are as described herein. Also provided are pharmaceutical compositions comprising compounds of Formula I and methods of using such compounds and compositions.
Abstract translation: 本发明提供了式I-I的嘧啶化合物及其实施方案。在其中R 1，R 2，R 3，R 4，R 5，R 6，m，n和“het”环如本文所述的式I-I中。 还提供了包含式I化合物和使用这些化合物和组合物的方法的药物组合物。
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公开(公告)号：US11963994B2
公开(公告)日：2024-04-23
申请号：US17392724
申请日：2021-08-03
Applicant: GENENTECH, INC.
Inventor： Frederick Cohen , Lewis J. Gazzard , Vickie Hsiao-Wei Tsui , John A. Flygare
CPC classification number: A61K38/06 , A61K45/06 , C07K5/08 , C07K5/0804 , C07K5/0806 , C07K5/0812 , C07K5/0815 , A61K38/00
Abstract: Novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies and have the general formula I:
wherein R1, R2, R3, R4, R5 and R6 are as described herein.-
公开(公告)号：US11096982B2
公开(公告)日：2021-08-24
申请号：US16372940
申请日：2019-04-02
Applicant: GENENTECH, INC.
Inventor： Frederick Cohen , Lewis J. Gazzard , Vickie Hsiao-Wei Tsui , John A. Flygare
Abstract: Novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies and have the general formula I: wherein R1, R2, R3, R4, R5 and R6 are as described herein.
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