公开(公告)号：US20240400579A1

公开(公告)日：2024-12-05

申请号：US18670520

申请日：2024-05-21

Applicant: GENENTECH, INC. ,  CONVELO THERAPEUTICS, INC.

Inventor： William VERNIER ,  Matthew VOLGRAF ,  Marie-Gabrielle BRAUN ,  Georgette Marie CASTANEDO ,  Paul Anthony GIBBONS ,  James Guy BREITENBUCHER ,  Drew ADAMS ,  Brad LANG

IPC: C07D495/10 ,  A61K31/407 ,  A61K31/4155 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/506

Abstract: The subject matter described herein is directed to myelin-promoting compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds for the treatment of myelin-related disorders.

公开(公告)号：US20230212153A1

公开(公告)日：2023-07-06

申请号：US18052851

申请日：2022-11-04

Applicant: Genentech, Inc.

Inventor： Malcolm HUESTIS ,  Michael John LAMBRECHT ,  Jun LIANG ,  Man Un UNG ,  Xiaojing WANG ,  Jason Robert ZBIEG ,  Bing-Yan Zhu ,  Lisa Marie BARTON ,  Fabio BROCCATELLI ,  Georgette Marie CASTANEDO ,  Araz JAKALIAN ,  Robin LAROUCHE-GAUTHIER ,  Arun YADAV

IPC: C07D403/12 ,  A61P35/00 ,  C07D493/08 ,  C07D405/14 ,  C07D403/14 ,  C07D409/14 ,  C07D401/14

CPC classification number: C07D403/12 ,  A61P35/00 ,  C07D493/08 ,  C07D405/14 ,  C07D403/14 ,  C07D409/14 ,  C07D401/14

Abstract: A compound, of formula (I):




suitable for treating a cancer wherein the cancer is susceptible to inhibition of Cbl-B.