公开(公告)号：US20210147562A1

公开(公告)日：2021-05-20

申请号：US17081784

申请日：2020-10-27

Applicant: Genentech, Inc.

Inventor： Gregory LAZAR ,  Jeong KIM ,  Jing ZHU ,  Yanli YANG ,  Randall BREZSKI

IPC: C07K16/28 ,  C07K16/32 ,  A61K47/68 ,  A61K38/02 ,  A61K39/395

Abstract: Provided herein are antigen binding polypeptides and complexes thereof having agonist activity. Also provided are methods for screening for complexes or polypeptides having agonist activity, enhancing the agonist activity of a polypeptide, and for agonizing a cell surface receptor using the complexes and polypeptide described herein.