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公开(公告)号：US20220348559A1
公开(公告)日：2022-11-03
申请号：US17198238
申请日：2021-03-10
Applicant: Genentech, Inc.
Inventor： Snahel PATEL , Gregory HAMILTON , Craig STIVALA , Huifen CHEN , Guiling ZHAO
IPC: C07D403/12 , C07D413/12 , C07D471/04 , C07D487/04 , C07D498/04 , C07D495/04 , C07D491/04 , C07D491/10 , C07D413/14 , C07D491/044 , C07D491/048 , C07D491/052 , C07D519/00
Abstract: The invention provides novel compounds having the general formula I: wherein R1, X, Z1, L, n, the A ring, the B ring, and the C ring are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds.
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公开(公告)号：US20160310611A1
公开(公告)日：2016-10-27
申请号：US15104388
申请日：2014-12-16
Applicant: GENENTECH INC. , MEDIMMUNE LIMITED
Inventor： John FLYGARE , Janet GUNZNER-TOSTE , Thomas PILLOW , Brian SAFINA , Vishal VERMA , Binqing WEI , Guiling ZHAO , Leanna STABEN , Philip Wilson HOWARD , Luke MASTERSON
IPC: A61K47/48 , C07K16/30 , A61K31/5517 , C07K16/28
Abstract: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, pharmaceutical compositions containing them, and to their use in therapy for the prevention treatment of cancer.
Abstract translation: 本发明涉及肽模拟接头及其抗体药物偶联物，含有它们的药物组合物及其在预防癌症治疗中的用途。
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公开(公告)号：US20160002266A1
公开(公告)日：2016-01-07
申请号：US14382210
申请日：2013-03-01
Applicant: GENENTECH, INC. , FORMA TM, LLC
Inventor： Kenneth W BAIR , Timm R BAUMEISTER , Peter DRAGOVICH , Xiongcai LIU , Snahel PATEL , Po-Wai YUEN , Mark ZAK , Guiling ZHAO , Yamin ZHANG , Xiaozhang ZHENG
IPC: C07D519/00 , A61K31/438 , C07D495/04 , C07D487/04 , A61K31/519 , A61K45/06 , A61K31/5377 , A61K31/541 , A61K31/496 , A61K31/497 , A61K31/501 , C07D471/04 , C07D491/048
CPC classification number: C07D519/00 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04
Abstract: Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
Abstract translation: 提供酰氨基螺环酰胺和磺酰胺化合物，包含这些化合物的药物组合物，以及使用这些化合物的治疗方法。
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公开(公告)号：US20240300974A1
公开(公告)日：2024-09-12
申请号：US18516014
申请日：2023-11-21
Applicant: Genentech, Inc.
Inventor： Snahel PATEL , Gregory HAMILTON , Guiling ZHAO , Huifen CHEN , Blake DANIELS , Craig STIVALA
IPC: C07D498/04 , A61P1/00 , A61P17/06 , A61P19/02 , A61P21/00 , A61P25/16 , A61P25/28 , C07D235/12 , C07D471/04 , C07D487/04
CPC classification number: C07D498/04 , A61P25/16 , A61P25/28 , C07D235/12 , C07D471/04 , C07D487/04 , A61P1/00 , A61P17/06 , A61P19/02 , A61P21/00
Abstract: The invention provides novel compounds having the general formula I:
wherein R1, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.-
Patent Agency Ranking
公开(公告)号：US20190100530A1
公开(公告)日：2019-04-04
申请号：US16034207
申请日：2018-07-12
Applicant: Genentech, Inc.
Inventor： Snahel PATEL , Gregory HAMILTON , Guiling ZHAO , Huifen CHEN , Blake DANIELS , Craig STIVALA
IPC: C07D498/04 , C07D487/04 , C07D471/04 , C07D235/12
Abstract: The invention provides novel compounds having the general formula I: wherein R1, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.
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公开(公告)号：US20210340151A1
公开(公告)日：2021-11-04
申请号：US17371001
申请日：2021-07-08
Applicant: Genentech, Inc.
Inventor： Snahel PATEL , Gregory HAMILTON , Guiling ZHAO , Huifen CHEN , Blake DANIELS , Craig STIVALA
IPC: C07D487/04
Abstract: Some embodiments of the invention provide compounds having the general formula I: wherein R1, R2, R3a and R3b are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.
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公开(公告)号：US20210139504A1
公开(公告)日：2021-05-13
申请号：US17147449
申请日：2021-01-12
Applicant: Genentech, Inc.
Inventor： Snahel PATEL , Gregory HAMILTON , Guiling ZHAO , Huifen CHEN , Blake DANIELS , Craig STIVALA
IPC: C07D498/04 , C07D487/04 , A61P25/16 , A61P25/28 , C07D235/12 , C07D471/04
Abstract: The invention provides novel compounds having the general formula I: wherein R1, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.
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公开(公告)号：US20200283446A1
公开(公告)日：2020-09-10
申请号：US16844952
申请日：2020-04-09
Applicant: Genentech, Inc.
Inventor： Huifen CHEN , Gregory HAMILTON , Snahel PATEL , Guiling ZHAO , Blake DANIELS , Craig STIVALA
IPC: C07D487/04 , C07D519/00 , A61P25/28
Abstract: The invention provides novel compounds having the general formula I: or pharmaceutically acceptable salts thereof, wherein RA, RB1, RB2, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.
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公开(公告)号：US20200157240A1
公开(公告)日：2020-05-21
申请号：US16696455
申请日：2019-11-26
Applicant: GENENTECH INC. , MEDIMMUNE LIMITED
Inventor： John FLYGARE , Janet GUNZNER-TOSTE , Thomas PILLOW , Brian SAFINA , Vishal VERMA , Binqing WEI , Guiling ZHAO , Leanna STABEN , Philip Wilson HOWARD , Luke MASTERSON
IPC: C07K16/30 , C07K16/28 , A61K31/5517 , A61K47/68
Abstract: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof pharmaceutical compositions containing them, and to their use in therapy for the prevention treatment of cancer.
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