-
公开(公告)号:US20170001990A1
公开(公告)日:2017-01-05
申请号:US15266222
申请日:2016-09-15
Applicant: Genentech, Inc.
Inventor: Jinhua CHEN , Charles Z. DING , Peter DRAGOVICH , Benjamin FAUBER , Zhenting GAO , Sharada S. LABADIE , Kwong Wah LAI , Hans Edward PURKEY , Kirk ROBARGE , Binqing WEI , Aihe ZHOU
IPC: C07D409/14 , C07D401/04 , C07D417/04 , C07D491/107 , C07D211/86 , C07D417/14 , C07D491/048 , C07D405/14 , C07D491/08 , C07D498/08 , C07D409/04 , C07D413/14
CPC classification number: C07D409/14 , C07D211/86 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/08 , C07D491/048 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The invention provides novel compounds having the general formula: and tautomers and pharmaceutically acceptable salts thereof, wherein A1, A2, A3, A4, R1, R4, R5, R6, R7 and R8 are as defined herein, compositions including the compounds and methods of using the compounds.
Abstract translation: 本发明提供具有通式(I)的新化合物及其互变异构体及其药学上可接受的盐,其中A1,A2,A3,A4,R1,R4,R5,R6,R7和R8如本文所定义,包括化合物和 使用化合物的方法。