公开(公告)号：US20230025834A1

公开(公告)日：2023-01-26

申请号：US17447361

申请日：2021-09-10

Applicant: Genentech, Inc.

Inventor： Guosheng WU ,  Emily J. HANAN ,  Marie-Gabrielle BRAUN ,  Sharada S. LABADIE ,  Keira GARLAND ,  Richard M. PASTOR ,  Paul Anthony GIBBONS ,  Yuhong FU ,  Yun-Xing CHENG

IPC: C07K7/56

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of lipoprotein signal peptidase II (LspA), a key protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

公开(公告)号：US20170001990A1

公开(公告)日：2017-01-05

申请号：US15266222

申请日：2016-09-15

Applicant: Genentech, Inc.

Inventor： Jinhua CHEN ,  Charles Z. DING ,  Peter DRAGOVICH ,  Benjamin FAUBER ,  Zhenting GAO ,  Sharada S. LABADIE ,  Kwong Wah LAI ,  Hans Edward PURKEY ,  Kirk ROBARGE ,  Binqing WEI ,  Aihe ZHOU

IPC: C07D409/14 ,  C07D401/04 ,  C07D417/04 ,  C07D491/107 ,  C07D211/86 ,  C07D417/14 ,  C07D491/048 ,  C07D405/14 ,  C07D491/08 ,  C07D498/08 ,  C07D409/04 ,  C07D413/14

CPC classification number: C07D409/14 ,  C07D211/86 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D487/08 ,  C07D491/048 ,  C07D491/08 ,  C07D491/107 ,  C07D498/08

Abstract: The invention provides novel compounds having the general formula: and tautomers and pharmaceutically acceptable salts thereof, wherein A1, A2, A3, A4, R1, R4, R5, R6, R7 and R8 are as defined herein, compositions including the compounds and methods of using the compounds.

Abstract translation: 本发明提供具有通式（I）的新化合物及其互变异构体及其药学上可接受的盐，其中A1，A2，A3，A4，R1，R4，R5，R6，R7和R8如本文所定义，包括化合物和 使用化合物的方法。