公开(公告)号：US20200308161A1

公开(公告)日：2020-10-01

申请号：US16903020

申请日：2020-06-16

申请人： Genentech, Inc.

发明人： Jack Alexander Terrett ,  Huifen Chen ,  Lea Constantineau-Forget ,  Robin Larouche-Gauthier ,  Luce Lépissier ,  Francis Beaumier ,  Martin Déry ,  Chantal Grand-Maître ,  Claudio Sturino ,  Matthew Volgraf ,  Elisia Villemure

IPC分类号： C07D413/14 ,  C07D473/30 ,  C07D471/04 ,  A61P29/00 ,  C07D513/04 ,  C07D487/04 ,  A61P25/00 ,  C07D498/04 ,  A61K31/427 ,  A61P23/00 ,  A61P11/00

摘要： The invention relates to methods of using compounds formula I: and pharmaceutically acceptable salts thereof wherein A, X, R1, R4 and n are as defined herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

公开(公告)号：US11655245B2

公开(公告)日：2023-05-23

申请号：US16903020

申请日：2020-06-16

申请人： Genentech, Inc.

发明人： Jack Alexander Terrett ,  Huifen Chen ,  Lea Constantineau-Forget ,  Robin Larouche-Gauthier ,  Luce Lépissier ,  Francis Beaumier ,  Martin Déry ,  Chantal Grand-Maître ,  Claudio Sturino ,  Matthew Volgraf ,  Elisia Villemure

IPC分类号： A61K31/427 ,  A61P11/00 ,  A61P23/00 ,  A61P25/00 ,  A61P29/00 ,  C07D513/04 ,  C07D473/30 ,  C07D487/04 ,  C07D498/04 ,  C07D471/04 ,  C07D413/14

CPC分类号： C07D413/14 ,  A61K31/427 ,  A61P11/00 ,  A61P23/00 ,  A61P25/00 ,  A61P29/00 ,  C07D471/04 ,  C07D473/30 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

摘要： The invention relates to methods of using compounds formula I:




and pharmaceutically acceptable salts thereof wherein A, X, R1, R4 and n are as defined herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

公开(公告)号：US10710994B2

公开(公告)日：2020-07-14

申请号：US16355352

申请日：2019-03-15

申请人： Genentech, Inc.

发明人： Jack Alexander Terrett ,  Huifen Chen ,  Lea Constantineau-Forget ,  Robin Larouche-Gauthier ,  Luce Lépissier ,  Francis Beaumier ,  Martin Déry ,  Chantal Grand-Maître ,  Claudio Sturino ,  Matthew Volgraf ,  Elisia Villemure

IPC分类号： A61P23/00 ,  A61P11/00 ,  A61P29/00 ,  A61P25/00 ,  C07D471/04 ,  C07D473/30 ,  C07D487/04 ,  C07D413/14 ,  C07D498/04 ,  C07D513/04 ,  A61K31/427

摘要： The invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof wherein A, X, R1, R4 and n are as defined herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

公开(公告)号：US20190284179A1

公开(公告)日：2019-09-19

申请号：US16355352

申请日：2019-03-15

申请人： Genentech, Inc.

发明人： Jack Alexander Terrett ,  Huifen Chen ,  Lea Constantineau-Forget ,  Robin Larouche-Gauthier ,  Luce Lépissier ,  Francis Beaumier ,  Martin Déry ,  Chantal Grand-Maître ,  Claudio Sturino ,  Matthew Volgraf ,  Elisia Villemure

IPC分类号： C07D413/14 ,  C07D473/30 ,  C07D471/04 ,  C07D498/04 ,  C07D513/04 ,  C07D487/04 ,  A61P25/00 ,  A61P29/00

摘要： The invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof wherein A, X, R1, R4 and n are as defined herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.