公开(公告)号：US12084429B2

公开(公告)日：2024-09-10

申请号：US17644993

申请日：2021-12-17

Applicant: Genentech, Inc.

Inventor： Sushant Malhotra ,  Jianfeng Xin ,  Steven Do ,  Jack Terrett

IPC: C07D401/04 ,  A61K9/00 ,  A61K31/517 ,  A61P35/00 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D471/14

CPC classification number: C07D401/14 ,  A61K9/0019 ,  A61K9/0053 ,  A61P35/00 ,  C07D405/14

Abstract: This invention pertains to fused ring compounds of Formula (I), as further detailed herein, which are used for the inhibition of Ras proteins, as well as compositions comprising these compounds and methods of treatment by their administration.

公开(公告)号：US10711004B2

公开(公告)日：2020-07-14

申请号：US16558718

申请日：2019-09-03

Applicant: Genentech, Inc.

Inventor： Huifen Chen ,  Brian Safina ,  Daniel Shore ,  Jack Terrett ,  Elisia Villemure ,  Matthew Volgraf ,  Stuart Ward ,  Aijun Lu ,  Robin Larouche-Gauthier ,  Francis Beaumier ,  Martin Dery ,  Lea Constantineau-Forget ,  Chantal Grand-Maitre ,  Luce Lepissier

IPC: C07D473/30 ,  C07D471/04 ,  C07D487/04 ,  C07D473/08

Abstract: The invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

公开(公告)号：US20230089126A1

公开(公告)日：2023-03-23

申请号：US17644993

申请日：2021-12-17

Applicant: Genentech, Inc.

Inventor： Sushant Malhotra ,  Jianfeng Xin ,  Steven Do ,  Jack Terrett

IPC: C07D401/14 ,  A61P35/00 ,  A61K9/00 ,  C07D405/14

Abstract: This invention pertains to fused ring compounds of Formula (I), as further detailed herein, which are used for the inhibition of Ras proteins, as well as compositions comprising these compounds and methods of treatment by their administration.

公开(公告)号：US20210230142A9

公开(公告)日：2021-07-29

申请号：US16679104

申请日：2019-11-08

Applicant: Genentech, Inc.

Inventor： Sushant Malhotra ,  Jianfeng Xin ,  Steven Do ,  Jack Terrett

IPC: C07D401/14 ,  C07D405/14 ,  A61P35/00 ,  A61K9/00

Abstract: This invention pertains to fused ring compounds of Formula (I), as further detailed herein, which are used for the inhibition of Ras proteins, as well as compositions comprising these compounds and methods of treatment by their administration.

公开(公告)号：US20250059163A1

公开(公告)日：2025-02-20

申请号：US18747054

申请日：2024-06-18

Applicant: Genentech, Inc.

Inventor： Sushant Malhotra ,  Jianfeng Xin ,  Steven Do ,  Jack Terrett

IPC: C07D401/14 ,  A61K9/00 ,  A61P35/00 ,  C07D405/14

Abstract: This invention pertains to fused ring compounds of Formula (I), as further detailed herein, which are used for the inhibition of Ras proteins, as well as compositions comprising these compounds and methods of treatment by their administration.

公开(公告)号：US11236068B2

公开(公告)日：2022-02-01

申请号：US16679104

申请日：2019-11-08

Applicant: Genentech, Inc.

Inventor： Sushant Malhotra ,  Jianfeng Xin ,  Steven Do ,  Jack Terrett

IPC: A61K31/517 ,  A61K31/519 ,  A61P35/00 ,  C07D401/14 ,  C07D403/14 ,  C07D407/14 ,  C07D471/04 ,  A61K9/00 ,  C07D405/14

Abstract: This invention pertains to fused ring compounds of Formula (I), as further detailed herein, which are used for the inhibition of Ras proteins, as well as compositions comprising these compounds and methods of treatment by their administration.