公开(公告)号：US10711004B2

公开(公告)日：2020-07-14

申请号：US16558718

申请日：2019-09-03

Applicant: Genentech, Inc.

Inventor： Huifen Chen ,  Brian Safina ,  Daniel Shore ,  Jack Terrett ,  Elisia Villemure ,  Matthew Volgraf ,  Stuart Ward ,  Aijun Lu ,  Robin Larouche-Gauthier ,  Francis Beaumier ,  Martin Dery ,  Lea Constantineau-Forget ,  Chantal Grand-Maitre ,  Luce Lepissier

IPC: C07D473/30 ,  C07D471/04 ,  C07D487/04 ,  C07D473/08

Abstract: The invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.