公开(公告)号：US20250129063A1

公开(公告)日：2025-04-24

申请号：US18913711

申请日：2024-10-11

Applicant: Genentech, Inc.

Inventor： Jakob FUHRMANN ,  Alberto Emilio GOBBI ,  Joachim RUDOLPH

IPC: C07D417/14 ,  A61K31/428 ,  A61K45/06 ,  A61K47/55

Abstract: The present disclosure relates to benzothiazole compounds and to methods of using such compounds. The present disclosure further relates to the use of the compounds described herein, or pharmaceutical compositions thereof, to prevent and/or treat a range of diseases, disorders, and conditions.

公开(公告)号：US20230391766A1

公开(公告)日：2023-12-07

申请号：US18195134

申请日：2023-05-09

Applicant: Genentech, Inc.

Inventor： Jakob FUHRMANN ,  Hao WU ,  Wayne J. FAIRBROTHER

IPC: C07D417/14 ,  C07D403/06 ,  C07D409/14 ,  A61K45/06

CPC classification number: C07D417/14 ,  C07D403/06 ,  C07D409/14 ,  A61K45/06

Abstract: The present disclosure relates to compounds comprising a VHL ligand moiety and to methods of using such compounds as ligands of VHL. The present disclosure further relates to the use of the compounds described herein, or pharmaceutical compositions thereof, to prevent and/or treat a range of diseases, disorders, and conditions.

公开(公告)号：US20230271944A1

公开(公告)日：2023-08-31

申请号：US18195141

申请日：2023-05-09

Applicant: Genentech, Inc.

Inventor： Jakob FUHRMANN ,  Hao WU ,  Wayne J. FAIRBROTHER

IPC: C07D403/06 ,  C07D405/14 ,  C07D401/14 ,  C07D409/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14

CPC classification number: C07D403/06 ,  C07D405/14 ,  C07D401/14 ,  C07D409/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present disclosure relates to compounds comprising a VHL ligand moiety and to methods of using such compounds as ligands of VHL. The present disclosure further relates to the use of the compounds described herein, or pharmaceutical compositions thereof, to prevent and/or treat a range of diseases, disorders, and conditions.

公开(公告)号：US20250129125A1

公开(公告)日：2025-04-24

申请号：US18902749

申请日：2024-09-30

Applicant: Genentech, Inc.

Inventor： Jakob FUHRMANN ,  Wayne FAIRBROTHER ,  Hao WU ,  Jeremy MURRAY

IPC: C07K7/64 ,  A61K31/551 ,  A61K38/00 ,  A61K47/64

Abstract: Provided, inter alia, are macrocyclic compounds.

公开(公告)号：US20220106361A1

公开(公告)日：2022-04-07

申请号：US17355022

申请日：2021-06-22

Applicant: Genentech, Inc.

Inventor： Jakob FUHRMANN ,  Wayne FAIRBROTHER ,  Hao WU ,  Jeremy MURRAY

IPC: C07K7/64 ,  A61K31/551 ,  A61K47/64

Abstract: Provided, inter alia, are macrocyclic compounds.