公开(公告)号：US20130143824A1

公开(公告)日：2013-06-06

申请号：US13654307

申请日：2012-10-17

Applicant: Genentech, Inc.

Inventor： Kurt Deshayes ,  Wayne J. FAIRBROTHER ,  John A. FLYGARE ,  Matthew C. FRANKLIN ,  Saloumeh FISCHER ,  Domagoj VUCIC

IPC: A61K38/08

CPC classification number: A61K38/08 ,  A61K38/00 ,  C07K7/08 ,  C07K14/001 ,  C07K14/4747 ,  C07K2319/00

Abstract: The present invention is directed to compositions of matter useful for the enhancement of apoptosis in mammals and to methods of using those compositions of matter for the same.

Abstract translation: 本发明涉及用于增强哺乳动物细胞凋亡的物质组合物，以及使用这些物质组合物的方法。

公开(公告)号：US20230391766A1

公开(公告)日：2023-12-07

申请号：US18195134

申请日：2023-05-09

Applicant: Genentech, Inc.

Inventor： Jakob FUHRMANN ,  Hao WU ,  Wayne J. FAIRBROTHER

IPC: C07D417/14 ,  C07D403/06 ,  C07D409/14 ,  A61K45/06

CPC classification number: C07D417/14 ,  C07D403/06 ,  C07D409/14 ,  A61K45/06

Abstract: The present disclosure relates to compounds comprising a VHL ligand moiety and to methods of using such compounds as ligands of VHL. The present disclosure further relates to the use of the compounds described herein, or pharmaceutical compositions thereof, to prevent and/or treat a range of diseases, disorders, and conditions.

公开(公告)号：US20230271944A1

公开(公告)日：2023-08-31

申请号：US18195141

申请日：2023-05-09

Applicant: Genentech, Inc.

Inventor： Jakob FUHRMANN ,  Hao WU ,  Wayne J. FAIRBROTHER

IPC: C07D403/06 ,  C07D405/14 ,  C07D401/14 ,  C07D409/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14

CPC classification number: C07D403/06 ,  C07D405/14 ,  C07D401/14 ,  C07D409/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present disclosure relates to compounds comprising a VHL ligand moiety and to methods of using such compounds as ligands of VHL. The present disclosure further relates to the use of the compounds described herein, or pharmaceutical compositions thereof, to prevent and/or treat a range of diseases, disorders, and conditions.