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公开(公告)号：US20230063741A1
公开(公告)日：2023-03-02
申请号：US17721970
申请日：2022-04-15
申请人： Genentech, Inc.
发明人： Justin SCHEER , Wenjun OUYANG , Richard VANDLEN , Philip E. HASS , Eric Gary STEFANICH , Ganesh A. KOLUMAM , Xiaoting WANG , Jed ROSS , Nicholas VAN BRUGGEN , Wyne P. LEE
摘要： The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.
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公开(公告)号：US20190177389A1
公开(公告)日：2019-06-13
申请号：US16196829
申请日：2018-11-20
申请人： Genentech, Inc.
发明人： Justin SCHEER , Wenjun OUYANG , Richard VANDLEN , Philip E. HASS , Eric Gary STEFANICH , Ganesh A. KOLUMAM , Xiaoting WANG , Jed ROSS , Nicholas VAN BRUGGEN , Wyne P. LEE
摘要： The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.
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3.发明申请公开(公告)号：US20160368985A1
公开(公告)日：2016-12-22
申请号：US15184690
申请日：2016-06-16
申请人： Genentech, Inc.
发明人： Isidro HOTZEL , Teemu T. JUNTTILA , Ji LI , Justin SCHEER , Danielle DICARA , Diego ELLERMAN , Christoph SPIESS , Paul J. CARTER
IPC分类号： C07K16/28 , G01N33/574 , A61K45/06 , A61K47/48 , C07K16/30 , A61K39/395
CPC分类号： C07K16/283 , A61K39/39558 , A61K45/06 , A61K47/6849 , A61K47/6851 , A61K2039/505 , A61K2039/507 , C07K16/2809 , C07K16/2827 , C07K16/30 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/62 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/57492 , G01N2333/70535
摘要： The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.
摘要翻译： 本发明涉及抗FcRH5抗体，包括抗FcRH5抗体，其包含FcRH5结合结构域和CD3结合结构域（例如，FcRH5T细胞依赖性双特异性（TDB）抗体）及其使用方法。
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公开(公告)号：US20220002386A1
公开(公告)日：2022-01-06
申请号：US17171962
申请日：2021-02-09
申请人： Genentech, Inc.
发明人： Justin SCHEER , Whitney SHATZ , Domingos NG
摘要： Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes located on a single molecule or located on different molecules.
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公开(公告)号：US20190185584A1
公开(公告)日：2019-06-20
申请号：US16045539
申请日：2018-07-25
申请人： Genentech, Inc.
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/244 , C07K16/247 , C07K16/2863 , C07K16/30 , C07K2317/31 , C07K2317/526 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , Y02A50/41
摘要： Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.
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公开(公告)号：US20190177388A1
公开(公告)日：2019-06-13
申请号：US16196823
申请日：2018-11-20
申请人： Genentech, Inc.
发明人： Justin SCHEER , Wenjun OUYANG , Richard VANDLEN , Philip E. HASS , Eric Gary STEFANICH , Ganesh A. KOLUMAM , Xiaoting WANG , Jed ROSS , Nicholas VAN BRUGGEN , Wyne P. LEE
摘要： The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.
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公开(公告)号：US20180362608A1
公开(公告)日：2018-12-20
申请号：US15801867
申请日：2017-11-02
申请人： Genentech, Inc.
发明人： Justin SCHEER , Wenjun OUYANG , Richard VANDLEN , Philip E. HASS , Eric Gary STEFANICH , Ganesh A. KOLUMAM , Xiaoting WANG , Jed ROSS , Nicholas VAN BRUGGEN , Wyne P. LEE
摘要： The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.
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公开(公告)号：US20180355009A1
公开(公告)日：2018-12-13
申请号：US16049633
申请日：2018-07-30
申请人： Genentech, Inc.
CPC分类号： C07K14/54 , A61K31/573 , A61K38/20 , A61K45/06 , A61P1/04 , C07K7/06 , C07K2319/30
摘要： The invention relates to IL-22 Fc fusion protein, composition comprising the IL-22 Fc fusion protein, and method of using the composition for the treatment of diseases, especially inflammatory bowel diseases.
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公开(公告)号：US20170088596A1
公开(公告)日：2017-03-30
申请号：US15369236
申请日：2016-12-05
申请人： Genentech, Inc.
发明人： Justin SCHEER , Wenjun OUYANG , Richard VANDLEN , Philip E. HASS , Eric Gary STEFANICH , Ganesh A. KOLUMAM , Xiaoting WANG , Jed ROSS , Nicholas VAN BRUGGEN , Wyne P. LEE
IPC分类号： C07K14/54
CPC分类号： C07K14/54 , A61K38/00 , A61K38/20 , A61K47/38 , C07K16/2866 , C07K2319/30
摘要： The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.
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10.发明申请IL-22 POLYPEPTIDES AND IL-22 Fc FUSION PROTEINS AND METHODS OF USE 审中-公开IL-22多聚酶和IL-22 Fc融合蛋白及其使用方法公开(公告)号：US20170008942A1
公开(公告)日：2017-01-12
申请号：US15217790
申请日：2016-07-22
申请人： Genentech, Inc.
发明人： Justin SCHEER , Wenjun OUYANG , Richard VANDLEN , Philip E. HASS , Eric Gary STEFANICH , Ganesh A. KOLUMAM , Xiaoting WANG , Jed ROSS , Nicholas VAN BRUGGEN , Wyne P. LEE
CPC分类号： C07K14/54 , A61K38/00 , A61K38/20 , A61K47/38 , C07K16/2866 , C07K2319/30
摘要： The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.
摘要翻译： 本发明涉及IL-22多肽，IL-22 Fc融合蛋白和IL-22激动剂，包含其的组合物，制备方法和使用该组合物治疗疾病的方法。 本发明还涉及IL-22受体相关试剂及其使用方法。
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