公开(公告)号：US11040985B2

公开(公告)日：2021-06-22

申请号：US16513621

申请日：2019-07-16

Applicant: Genentech, Inc.

Inventor： Jeffrey A. Stafford ,  James M. Veal ,  Lynnie Lin Trzoss ,  Christopher McBride

IPC: C07D498/04 ,  A61P37/02

Abstract: The present disclosure relates to novel sulfonylurea and sulfonyl thiourea compounds and related compounds and their use in treating a disease or condition responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.

公开(公告)号：US11702428B2

公开(公告)日：2023-07-18

申请号：US17686183

申请日：2022-03-03

Applicant: Genentech, Inc.

Inventor： Jeffrey A. Stafford ,  James M. Veal ,  Lynnie Lin Trzoss ,  Christopher McBride

IPC: C07D498/04 ,  A61P37/02

CPC classification number: C07D498/04 ,  A61P37/02

Abstract: The present disclosure relates to novel sulfonylurea and sulfonyl thiourea compounds and related compounds and their use in treating a disease or condition responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.

公开(公告)号：US12234245B2

公开(公告)日：2025-02-25

申请号：US17150349

申请日：2021-01-15

Applicant: Genentech, Inc.

Inventor： Christopher McBride ,  Lynnie Lin Trzoss ,  Amogh Boloor ,  Nadezda V. Sokolova ,  Richard M. Pastor ,  Steven Thomas Staben ,  Craig Stivala ,  Matthew Volgraf ,  Sarah M. Bronner

IPC: C07D498/04 ,  A61P31/04 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  C07D231/18 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04

Abstract: The present disclosure relates to novel sulfonimidamide compounds and related compounds and their use in treating a disorder responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.

公开(公告)号：US11560391B2

公开(公告)日：2023-01-24

申请号：US17150380

申请日：2021-01-15

Applicant: Genentech, Inc.

Inventor： Jeffrey A. Stafford ,  James M. Veal ,  Lynnie Lin Trzoss ,  Christopher McBride ,  Richard M. Pastor ,  Steven Thomas Staben ,  Craig Stivala ,  Matthew Volgraf

IPC: C07D498/04

Abstract: The present disclosure relates to novel sulfonylurea compounds and related compounds useful in treating a disorder responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.