公开(公告)号：US20180072683A1

公开(公告)日：2018-03-15

申请号：US15801192

申请日：2017-11-01

Applicant: Genentech, Inc.

Inventor： Benjamin Fauber ,  James J. Crawford ,  Sarah M. Bronner ,  Monique Bodil van Niel ,  Andrew Cridland ,  Emanuela Gancia ,  Christopher Hurley ,  Jonathan Killen ,  Stuart Ward

IPC: C07D237/26

CPC classification number: C07D237/26 ,  C07D237/28

Abstract: Compounds of formula I: or pharmaceutical salts thereof, wherein m, A, X, Y, Z, R1, R2, R3, R4 and R5are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

公开(公告)号：US20190263794A1

公开(公告)日：2019-08-29

申请号：US16398795

申请日：2019-04-30

Applicant: Genentech, Inc.

Inventor： Sarah M. Bronner ,  James J. Crawford ,  Andrew Cridland ,  Patrick Cyr ,  Benjamin Fauber ,  Emanuela Gancia ,  Alberto Gobbi ,  Christopher Hurley ,  Jonathan Killen ,  Wendy Lee ,  Olivier Rene ,  Monique Bodil Van Niel ,  Stuart Ward ,  Paul Winship ,  Jason Zbieg

IPC: C07D413/14 ,  C07D403/14 ,  C07D405/14

Abstract: Compounds of formula I: or pharmaceutical salts thereof, wherein m, n, p, q A, B, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

公开(公告)号：US10280144B2

公开(公告)日：2019-05-07

申请号：US15801192

申请日：2017-11-01

Applicant: Genentech, Inc.

Inventor： Benjamin Fauber ,  James J. Crawford ,  Sarah M. Bronner ,  Monique Bodil van Niel ,  Andrew Cridland ,  Emanuela Gancia ,  Christopher Hurley ,  Jonathan Killen ,  Stuart Ward

IPC: C07D237/26 ,  C07D237/28

Abstract: Compounds of formula I: or pharmaceutical salts thereof, wherein m, A, X, Y, Z, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

公开(公告)号：US12234245B2

公开(公告)日：2025-02-25

申请号：US17150349

申请日：2021-01-15

Applicant: Genentech, Inc.

Inventor： Christopher McBride ,  Lynnie Lin Trzoss ,  Amogh Boloor ,  Nadezda V. Sokolova ,  Richard M. Pastor ,  Steven Thomas Staben ,  Craig Stivala ,  Matthew Volgraf ,  Sarah M. Bronner

IPC: C07D498/04 ,  A61P31/04 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  C07D231/18 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04

Abstract: The present disclosure relates to novel sulfonimidamide compounds and related compounds and their use in treating a disorder responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.

公开(公告)号：US11008312B2

公开(公告)日：2021-05-18

申请号：US16398795

申请日：2019-04-30

Applicant: Genentech, Inc.

Inventor： Sarah M. Bronner ,  James J. Crawford ,  Andrew Cridland ,  Patrick Cyr ,  Benjamin Fauber ,  Emanuela Gancia ,  Alberto Gobbi ,  Christopher Hurley ,  Jonathan Killen ,  Wendy Lee ,  Olivier Rene ,  Monique Bodil Van Niel ,  Stuart Ward ,  Paul Winship ,  Jason Zbieg

IPC: C07D413/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D401/14

Abstract: Compounds of formula I: or pharmaceutical salts thereof, wherein m, n, p, q A, B, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.