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1.发明授权Use of a combination of a MEK inhibitor and an ERK inhibitor for treatment of hyperproliferative diseases 有权使用MEK抑制剂和ERK抑制剂的组合来治疗过度增殖性疾病公开(公告)号：US09532987B2
公开(公告)日：2017-01-03
申请号：US14473311
申请日：2014-08-29
Applicant: Genentech, Inc.
Inventor： Marcia Belvin , John Moffat , Mark Merchant
IPC: A61K31/506 , A61K31/397 , A61K31/435 , A61K31/437 , A61K31/5025
CPC classification number: A61K31/506 , A61K31/397 , A61K31/435 , A61K31/437 , A61K31/5025 , A61K2300/00
Abstract: The invention provides combinations comprising a MEK inhibitor (such as GDC-0973 or GDC-0623), or a pharmaceutically acceptable salt thereof and an ERK inhibitor (such as GDC-0994). The combinations are particularly useful for treating hyperproliferative disorders, such as cancer.
Abstract translation: 本发明提供了包含MEK抑制剂（例如GDC-0973或GDC-0623）或其药学上可接受的盐和ERK抑制剂（例如GDC-0994）的组合。 这些组合对于治疗过度增殖性疾病如癌症特别有用。
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Patent Agency Ranking
公开(公告)号：US20180280408A1
公开(公告)日：2018-10-04
申请号：US15897032
申请日：2018-02-14
Applicant: Genentech, Inc.
Inventor： Marcia Belvin , Lori Friedman , Deepak Sampath , Jeffrey Wallin
IPC: A61K31/553 , A61K39/395 , G01N33/50 , C12Q1/6886 , A61K45/06 , A61K31/138 , A61K31/337 , A61K31/357 , A61K31/4196 , A61K31/437 , A61K31/4523 , A61K31/513 , A61K31/555 , A61K31/565 , A61K31/573 , A61K31/7068
Abstract: Methods and compositions are provided for treating hyperproliferative disorders in patients with a PI3K inhibitor, GDC-0032 as a single agent or in combination with chemotherapeutic agents.
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3.发明申请USE OF A COMBINATION OF A MEK INHIBITOR AND AN ERK INHIBITOR FOR TREATMENT OF HYPERPROLIFERATIVE DISEASES 审中-公开使用MEK抑制剂和ERK抑制剂联合用于治疗高增殖性疾病公开(公告)号：US20150111869A1
公开(公告)日：2015-04-23
申请号：US14473311
申请日：2014-08-29
Applicant: Genentech, Inc.
Inventor： Marcia Belvin , John Moffat , Mark Merchant
IPC: A61K31/506 , A61K31/397
CPC classification number: A61K31/506 , A61K31/397 , A61K31/435 , A61K31/437 , A61K31/5025 , A61K2300/00
Abstract: The invention provides combinations comprising a MEK inhibitor (such as GDC-0973 or GDC-0623), or a pharmaceutically acceptable salt thereof and an ERK inhibitor (such as GDC-0994). The combinations are particularly useful for treating hyperproliferative disorders, such as cancer.
Abstract translation: 本发明提供了包含MEK抑制剂（例如GDC-0973或GDC-0623）或其药学上可接受的盐和ERK抑制剂（例如GDC-0994）的组合。 这些组合对于治疗过度增殖性疾病如癌症特别有用。
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4.发明申请MUTANT SELECTIVITY AND COMBINATIONS OF A PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUND AND CHEMOTHERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER 审中-公开磷酸三辛酯抑制剂化合物和治疗癌症的化学治疗剂的突变选择性和组合公开(公告)号：US20160045515A1
公开(公告)日：2016-02-18
申请号：US14791783
申请日：2015-07-06
Applicant: Genentech, Inc.
Inventor： Marcia Belvin , Lori Friedman , Deepak Sampath , Jeffrey Wallin
IPC: A61K31/553 , C12Q1/68 , A61K45/06
CPC classification number: A61K31/553 , A61K31/138 , A61K31/337 , A61K31/357 , A61K31/4196 , A61K31/437 , A61K31/4523 , A61K31/513 , A61K31/555 , A61K31/565 , A61K31/573 , A61K31/7068 , A61K39/39558 , A61K45/06 , A61P35/00 , C07K16/32 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/142 , C12Q2600/156 , C12Q2600/158 , G01N33/5011 , G01N33/5023 , A61K2300/00
Abstract: Methods and compositions are provided for treating hyperproliferative disorders in patients with a PI3K inhibitor, GDC-0032 as a single agent or in combination with chemotherapeutic agents.
Abstract translation: 提供了用于治疗患有PI3K抑制剂，GDC-0032作为单一药剂或与化学治疗剂组合的患者中的过度增殖性疾病的方法和组合物。
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5.发明授权Mutant selectivity and combinations of a phosphoinositide 3-kinase inhibitor compound and chemotherapeutic agents for the treatment of cancer 有权磷酸肌醇3-激酶抑制剂化合物的突变选择性和组合以及用于治疗癌症的化学治疗剂公开(公告)号：US09107926B2
公开(公告)日：2015-08-18
申请号：US13912281
申请日：2013-06-07
Applicant: Genentech, Inc.
Inventor： Marcia Belvin , Lori Friedman , Deepak Sampath , Jeffrey Wallin
IPC: C07D498/00 , C07D513/00 , A61K31/553 , A61K39/395 , A61K45/06 , A61K31/138 , A61K31/337 , A61K31/357 , A61K31/4196 , A61K31/437 , A61K31/4523 , A61K31/513 , A61K31/555 , A61K31/565 , A61K31/573 , A61K31/7068 , G01N33/50 , C12Q1/68 , C07K16/32
CPC classification number: A61K31/553 , A61K31/138 , A61K31/337 , A61K31/357 , A61K31/4196 , A61K31/437 , A61K31/4523 , A61K31/513 , A61K31/555 , A61K31/565 , A61K31/573 , A61K31/7068 , A61K39/39558 , A61K45/06 , C07K16/32 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/142 , C12Q2600/156 , C12Q2600/158 , G01N33/5011 , G01N33/5023 , A61K2300/00
Abstract: Methods and compositions are provided for treating hyperproliferative disorders in patients with a PI3K inhibitor, GDC-0032 as a single agent or in combination with chemotherapeutic agents.
Abstract translation: 提供了用于治疗患有PI3K抑制剂，GDC-0032作为单一药剂或与化学治疗剂组合的患者中的过度增殖性疾病的方法和组合物。
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6.发明申请公开(公告)号：US20130345217A1
公开(公告)日：2013-12-26
申请号：US14012673
申请日：2013-08-28
Applicant: Genentech, Inc.
Inventor： Marcia Belvin , Lori Friedman , Klaus P. Hoeflich , Jeffrey Wallin
IPC: A61K31/5377 , A61K31/4523
CPC classification number: A61K31/5377 , A61K31/4523 , A61K31/505
Abstract: Combinations of PI3K inhibitor compounds having Formulas I and II and chemotherapeutic agents, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for treating hyperproliferative disorders such as cancer. Methods of using such combinations for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
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