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1.发明申请USE OF A COMBINATION OF A MEK INHIBITOR AND AN ERK INHIBITOR FOR TREATMENT OF HYPERPROLIFERATIVE DISEASES 审中-公开使用MEK抑制剂和ERK抑制剂联合用于治疗高增殖性疾病公开(公告)号：US20150111869A1
公开(公告)日：2015-04-23
申请号：US14473311
申请日：2014-08-29
Applicant: Genentech, Inc.
Inventor： Marcia Belvin , John Moffat , Mark Merchant
IPC: A61K31/506 , A61K31/397
CPC classification number: A61K31/506 , A61K31/397 , A61K31/435 , A61K31/437 , A61K31/5025 , A61K2300/00
Abstract: The invention provides combinations comprising a MEK inhibitor (such as GDC-0973 or GDC-0623), or a pharmaceutically acceptable salt thereof and an ERK inhibitor (such as GDC-0994). The combinations are particularly useful for treating hyperproliferative disorders, such as cancer.
Abstract translation: 本发明提供了包含MEK抑制剂（例如GDC-0973或GDC-0623）或其药学上可接受的盐和ERK抑制剂（例如GDC-0994）的组合。 这些组合对于治疗过度增殖性疾病如癌症特别有用。
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2.发明授权Use of a combination of a MEK inhibitor and an ERK inhibitor for treatment of hyperproliferative diseases 有权使用MEK抑制剂和ERK抑制剂的组合来治疗过度增殖性疾病公开(公告)号：US09532987B2
公开(公告)日：2017-01-03
申请号：US14473311
申请日：2014-08-29
Applicant: Genentech, Inc.
Inventor： Marcia Belvin , John Moffat , Mark Merchant
IPC: A61K31/506 , A61K31/397 , A61K31/435 , A61K31/437 , A61K31/5025
CPC classification number: A61K31/506 , A61K31/397 , A61K31/435 , A61K31/437 , A61K31/5025 , A61K2300/00
Abstract: The invention provides combinations comprising a MEK inhibitor (such as GDC-0973 or GDC-0623), or a pharmaceutically acceptable salt thereof and an ERK inhibitor (such as GDC-0994). The combinations are particularly useful for treating hyperproliferative disorders, such as cancer.
Abstract translation: 本发明提供了包含MEK抑制剂（例如GDC-0973或GDC-0623）或其药学上可接受的盐和ERK抑制剂（例如GDC-0994）的组合。 这些组合对于治疗过度增殖性疾病如癌症特别有用。
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公开(公告)号：US20140228384A1
公开(公告)日：2014-08-14
申请号：US13904922
申请日：2013-05-29
Applicant: Genentech, Inc.
Inventor： Daisy Bustos , Donald Kirkpatrick , Tracy Kleinheinz , John Moffat , Zejuan Sheng , Shuo Zhang , Haitao Zhu
IPC: G01N33/573
CPC classification number: G01N33/573 , G01N2333/912 , G01N2440/14 , G01N2500/04 , G01N2800/2835 , G01N2800/50 , G01N2800/52
Abstract: Biomarkers for screening subjects for Parkinson's disease and providing companion diagnostic tools for therapies using LRRK2 modulators, and assays for screening compounds and compositions for modulation of LRRK2 activity.
Abstract translation: 用于筛选帕金森病患者的生物标志物，并提供使用LRRK2调节剂治疗的配套诊断工具，以及筛选用于调节LRRK2活性的化合物和组合物的测定。
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