公开(公告)号：US20230077255A1

公开(公告)日：2023-03-09

申请号：US17718162

申请日：2022-04-11

Applicant: Genentech, Inc.

Inventor： Mary MONTTI ,  Richard L. Beardsley ,  Michael S. Chinn

IPC: G01N30/96 ,  G01N30/36 ,  B01D15/38

Abstract: The invention provides methods for quantifying a non-ionic surfactant in a composition comprising a polypeptide and the non-ionic surfactant, where the quantification exhibits reduced interference between the non-ionic surfactant and the polypeptide. Also provided are methods where the composition further includes N-acetyl tryptophan, and the quantification exhibits reduced interference between the non-ionic surfactant, the polypeptide, and N-acetyl tryptophan.

公开(公告)号：US20190178859A1

公开(公告)日：2019-06-13

申请号：US16275849

申请日：2019-02-14

Applicant: Genentech, Inc.

Inventor： Mary MONTTI ,  Richard L. BEARDSLEY ,  Michael S. CHINN

IPC: G01N30/96 ,  G01N30/36

Abstract: The invention provides methods for quantifying a non-ionic surfactant in a composition comprising a polypeptide and the non-ionic surfactant, where the quantification exhibits reduced interference between the non-ionic surfactant and the polypeptide. Also provided are methods where the composition further includes N-acetyl tryptophan, and the quantification exhibits reduced interference between the non-ionic surfactant, the polypeptide, and N-acetyl tryptophan.