公开(公告)号：US11333644B2

公开(公告)日：2022-05-17

申请号：US16275849

申请日：2019-02-14

Applicant: Genentech, Inc.

Inventor： Mary Montti ,  Richard L. Beardsley ,  Michael S. Chinn

IPC: A61K47/10 ,  A61K47/26 ,  B01D15/38 ,  G01N30/36 ,  G01N30/96

Abstract: The invention provides methods for quantifying a non-ionic surfactant in a composition comprising a polypeptide and the non-ionic surfactant, where the quantification exhibits reduced interference between the non-ionic surfactant and the polypeptide. Also provided are methods where the composition further includes N-acetyl tryptophan, and the quantification exhibits reduced interference between the non-ionic surfactant, the polypeptide, and N-acetyl tryptophan.

公开(公告)号：US11680931B2

公开(公告)日：2023-06-20

申请号：US17718162

申请日：2022-04-11

Applicant: Genentech, Inc.

Inventor： Mary Montti ,  Richard L. Beardsley ,  Michael S. Chinn

IPC: A61K47/10 ,  A61K47/26 ,  B01D15/38 ,  G01N30/36 ,  G01N30/96

CPC classification number: G01N30/96 ,  B01D15/3847 ,  G01N30/36 ,  A61K47/10 ,  A61K47/26

Abstract: The invention provides methods for quantifying a non-ionic surfactant in a composition comprising a polypeptide and the non-ionic surfactant, where the quantification exhibits reduced interference between the non-ionic surfactant and the polypeptide. Also provided are methods where the composition further includes N-acetyl tryptophan, and the quantification exhibits reduced interference between the non-ionic surfactant, the polypeptide, and N-acetyl tryptophan.

公开(公告)号：US20230077255A1

公开(公告)日：2023-03-09

申请号：US17718162

申请日：2022-04-11

Applicant: Genentech, Inc.

Inventor： Mary MONTTI ,  Richard L. Beardsley ,  Michael S. Chinn

IPC: G01N30/96 ,  G01N30/36 ,  B01D15/38

Abstract: The invention provides methods for quantifying a non-ionic surfactant in a composition comprising a polypeptide and the non-ionic surfactant, where the quantification exhibits reduced interference between the non-ionic surfactant and the polypeptide. Also provided are methods where the composition further includes N-acetyl tryptophan, and the quantification exhibits reduced interference between the non-ionic surfactant, the polypeptide, and N-acetyl tryptophan.