公开(公告)号：US20250061965A1

公开(公告)日：2025-02-20

申请号：US18941251

申请日：2024-11-08

Applicant: Genentech, Inc.

Inventor： Zia KHAN ,  Matthew Lawrence ALBERT ,  G Scott CHANDLER

IPC: G16B20/20 ,  G16B30/00 ,  G16H10/40 ,  G16H20/40 ,  G16H50/30

Abstract: Provided herein are diagnostic and therapeutic methods for the treatment of cancer using polygenic risk scores (PRSs) for dermatological autoimmune diseases. In particular, the invention provides methods for patient selection and methods of treatment.

公开(公告)号：US20200172620A1

公开(公告)日：2020-06-04

申请号：US16788003

申请日：2020-02-11

Applicant: Genentech, Inc.

Inventor： Yvonne M. CHEN ,  Eugene Yu-Chuan CHIANG ,  Jane Louise GROGAN ,  Simon-Peter WILLIAMS ,  Matthew Lawrence ALBERT

IPC: C07K16/28 ,  A61K35/17 ,  A61K47/65 ,  G01N33/58 ,  A61K39/00

Abstract: Provided are anti-CD8 antibodies that bind human CD8 and do not stimulate or inhibit the activation of CD8+ T cells. Also provided are nucleic acids encoding such anti-CD8 antibodies, vectors comprising such nucleic acids, host cells comprising same, and methods of making such anti-CD8 antibodies. Also provided are anti-CD8 antibodies conjugated to a detectable label. Provided are methods of using such anti-CD8 antibodies to detect CD8+ T cells in a subject, monitor disease progress in a subject having cancer, and monitor treatment progress in a subject having cancer.

公开(公告)号：US20240018241A1

公开(公告)日：2024-01-18

申请号：US18346128

申请日：2023-06-30

Applicant: Genentech, Inc.

Inventor： Yvonne M. CHEN ,  Eugene Yu-Chuan CHIANG ,  Jane Louise GROGAN ,  Simon-Peter WILLIAMS ,  Matthew Lawrence ALBERT

IPC: C07K16/28 ,  A61K47/65 ,  A61K35/17 ,  A61K39/00

CPC classification number: C07K16/2815 ,  A61K47/65 ,  A61K35/17 ,  A61K39/0011 ,  A61K38/00

Abstract: Provided are anti-CD8 antibodies that bind human CD8 and do not stimulate or inhibit the activation of CD8+ T cells. Also provided are nucleic acids encoding such anti-CD8 antibodies, vectors comprising such nucleic acids, host cells comprising same, and methods of making such anti-CD8 antibodies. Also provided are anti-CD8 antibodies conjugated to a detectable label. Provided are methods of using such anti-CD8 antibodies to detect CD8+ T cells in a subject, monitor disease progress in a subject having cancer, and monitor treatment progress in a subject having cancer.

公开(公告)号：US20220115087A1

公开(公告)日：2022-04-14

申请号：US17395996

申请日：2021-08-06

Applicant: Genentech, Inc.

Inventor： Zia KHAN ,  Matthew Lawrence ALBERT ,  G Scott CHANDLER

IPC: G16B20/20 ,  G16B30/00 ,  G16H50/30 ,  G16H10/40 ,  G16H20/40

Abstract: Provided herein are diagnostic and therapeutic methods for the treatment of cancer using polygenic risk scores (PRSs) for dermatological autoimmune diseases. In particular, the invention provides methods for patient selection and methods of treatment.