公开(公告)号：US20150284458A1

公开(公告)日：2015-10-08

申请号：US14743933

申请日：2015-06-18

Applicant: GENENTECH, INC.

Inventor： Yvonne M. CHEN ,  Henry B. LOWMAN ,  Yves MULLER

IPC: C07K16/22 ,  C07K16/00

CPC classification number: C07K16/22 ,  A61K38/00 ,  B65H2801/87 ,  C07K16/00 ,  C07K16/005 ,  C07K16/24 ,  C07K2299/00 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: Antibody variants of parent antibodies are disclosed which have one or more amino acids inserted in a hypervariable region of the parent antibody and a binding affinity for a target antigen which is at least about two fold stronger than the binding affinity of the parent antibody for the antigen.

公开(公告)号：US20200172620A1

公开(公告)日：2020-06-04

申请号：US16788003

申请日：2020-02-11

Applicant: Genentech, Inc.

Inventor： Yvonne M. CHEN ,  Eugene Yu-Chuan CHIANG ,  Jane Louise GROGAN ,  Simon-Peter WILLIAMS ,  Matthew Lawrence ALBERT

IPC: C07K16/28 ,  A61K35/17 ,  A61K47/65 ,  G01N33/58 ,  A61K39/00

Abstract: Provided are anti-CD8 antibodies that bind human CD8 and do not stimulate or inhibit the activation of CD8+ T cells. Also provided are nucleic acids encoding such anti-CD8 antibodies, vectors comprising such nucleic acids, host cells comprising same, and methods of making such anti-CD8 antibodies. Also provided are anti-CD8 antibodies conjugated to a detectable label. Provided are methods of using such anti-CD8 antibodies to detect CD8+ T cells in a subject, monitor disease progress in a subject having cancer, and monitor treatment progress in a subject having cancer.

公开(公告)号：US20240018241A1

公开(公告)日：2024-01-18

申请号：US18346128

申请日：2023-06-30

Applicant: Genentech, Inc.

Inventor： Yvonne M. CHEN ,  Eugene Yu-Chuan CHIANG ,  Jane Louise GROGAN ,  Simon-Peter WILLIAMS ,  Matthew Lawrence ALBERT

IPC: C07K16/28 ,  A61K47/65 ,  A61K35/17 ,  A61K39/00

CPC classification number: C07K16/2815 ,  A61K47/65 ,  A61K35/17 ,  A61K39/0011 ,  A61K38/00

Abstract: Provided are anti-CD8 antibodies that bind human CD8 and do not stimulate or inhibit the activation of CD8+ T cells. Also provided are nucleic acids encoding such anti-CD8 antibodies, vectors comprising such nucleic acids, host cells comprising same, and methods of making such anti-CD8 antibodies. Also provided are anti-CD8 antibodies conjugated to a detectable label. Provided are methods of using such anti-CD8 antibodies to detect CD8+ T cells in a subject, monitor disease progress in a subject having cancer, and monitor treatment progress in a subject having cancer.