公开(公告)号：US20200172620A1

公开(公告)日：2020-06-04

申请号：US16788003

申请日：2020-02-11

Applicant: Genentech, Inc.

Inventor： Yvonne M. CHEN ,  Eugene Yu-Chuan CHIANG ,  Jane Louise GROGAN ,  Simon-Peter WILLIAMS ,  Matthew Lawrence ALBERT

IPC: C07K16/28 ,  A61K35/17 ,  A61K47/65 ,  G01N33/58 ,  A61K39/00

Abstract: Provided are anti-CD8 antibodies that bind human CD8 and do not stimulate or inhibit the activation of CD8+ T cells. Also provided are nucleic acids encoding such anti-CD8 antibodies, vectors comprising such nucleic acids, host cells comprising same, and methods of making such anti-CD8 antibodies. Also provided are anti-CD8 antibodies conjugated to a detectable label. Provided are methods of using such anti-CD8 antibodies to detect CD8+ T cells in a subject, monitor disease progress in a subject having cancer, and monitor treatment progress in a subject having cancer.

公开(公告)号：US20240018241A1

公开(公告)日：2024-01-18

申请号：US18346128

申请日：2023-06-30

Applicant: Genentech, Inc.

Inventor： Yvonne M. CHEN ,  Eugene Yu-Chuan CHIANG ,  Jane Louise GROGAN ,  Simon-Peter WILLIAMS ,  Matthew Lawrence ALBERT

IPC: C07K16/28 ,  A61K47/65 ,  A61K35/17 ,  A61K39/00

CPC classification number: C07K16/2815 ,  A61K47/65 ,  A61K35/17 ,  A61K39/0011 ,  A61K38/00

Abstract: Provided are anti-CD8 antibodies that bind human CD8 and do not stimulate or inhibit the activation of CD8+ T cells. Also provided are nucleic acids encoding such anti-CD8 antibodies, vectors comprising such nucleic acids, host cells comprising same, and methods of making such anti-CD8 antibodies. Also provided are anti-CD8 antibodies conjugated to a detectable label. Provided are methods of using such anti-CD8 antibodies to detect CD8+ T cells in a subject, monitor disease progress in a subject having cancer, and monitor treatment progress in a subject having cancer.

公开(公告)号：US20230192853A1

公开(公告)日：2023-06-22

申请号：US17640499

申请日：2020-09-03

Applicant: GENENTECH, INC. ,  F. Hoffmann-LA Roche AG

Inventor： James Thomas KOERBER ,  Alejandra Beatrice Urpi URRUTIA ,  Simon-Peter WILLIAMS ,  Christopher Williamson DAVIES ,  Shravan Kumar SRIRAMAN ,  Herman Singh GILL ,  James Richard KIEFER, Jr.

IPC: C07K16/28 ,  A61K51/10 ,  G01N33/574

CPC classification number: C07K16/2815 ,  A61K51/1027 ,  A61K51/1093 ,  G01N33/57492 ,  C07K2317/92 ,  C07K2317/569 ,  C07K2317/24 ,  C07K2317/22 ,  C07K2317/74

Abstract: Provided are CD8 binding agents comprising a VHH domain that specifically binds human CD8. Also provided are nucleic acids encoding such CD8 binding agents, vectors comprising such nucleic acids, host cells comprising same, and methods of making such CD8 binding agents. Also provided are CD8 binding agents having the VHH domain conjugated to a detectable label. Provided are methods of using such CD8 binding agents to detect CD8+ T cells, monitor disease progress, and monitor treatment progress in a subject having cancer, autoimmune disease or condition, transplant rejection or graft-versus-host disease.