公开(公告)号：US20240293829A1

公开(公告)日：2024-09-05

申请号：US18431838

申请日：2024-02-02

Applicant: Genentech, Inc.

Inventor： Nicholas RUMMEL ,  Patrick Daniel AHYOW

IPC: B04B7/00 ,  B33Y80/00 ,  C12M1/26

CPC classification number: B04B7/00 ,  B33Y80/00 ,  C12M33/10

Abstract: Provided herein are systems, devices and methods for harvesting biological cells with a centrifuge. A biological cell harvesting centrifuge apparatus may be provided with a rectangularly shaped base and 21 laterally spaced apart upright supports. Each upright support may extend vertically upward from the base and have a hollow core. Each upright support may be configured to slidably receive and support either one, two or four vertical edges of either one, two or four 15 mL micro bioreactor vessels. The 21 upright supports may be arranged in a 3×7 array such that they form a 2×6 array of receptacles configured to slidably receive and support 12 of the bioreactor vessels. The upright supports may be configured to support at least 80% of the vertical edges of the bioreactor vessels.

公开(公告)号：US20210238644A1

公开(公告)日：2021-08-05

申请号：US17172528

申请日：2021-02-10

Applicant: GENENTECH, INC.

Inventor： Inn Huam YUK ,  Patrick Daniel AHYOW ,  Anh Thuy NGUYEN DANG ,  Melissa Siu-Lan MUN ,  Kristen Leigh DOUGLAS ,  Robert David KISS

IPC: C12P21/00 ,  C07K16/28 ,  C12N5/00

Abstract: The presently disclosed subject matter relates to cell culture media and cell culture strategies for modulating the glycosylation pattern, e.g., fucosylation and/or galactosylation pattern, of a glycoprotein of interest, e.g., an antibody, as well as cell culture and glycoprotein compositions prepared using such media and/or strategies.