公开(公告)号：US20230181533A1

公开(公告)日：2023-06-15

申请号：US18105752

申请日：2023-02-03

Applicant: Genentech, Inc.

Inventor： Sreedhara ALAVATTAM ,  Mary MALLANEY ,  Parbir GREWAL

IPC: A61K31/405 ,  A61K39/395 ,  C07K16/24 ,  C12Q1/28 ,  G01N33/68 ,  C07K16/28

CPC classification number: A61K31/405 ,  A61K39/39533 ,  A61K39/39591 ,  C07K16/241 ,  C07K16/2878 ,  C12Q1/28 ,  G01N33/6854 ,  A61K2039/505 ,  C07K2317/55

Abstract: The invention provides formulations comprising a protein in combination with a compound that prevents oxidation of the protein. The invention also provides methods for making such formulations and methods of using such formulations. The invention further provides methods of screening for compounds that prevent oxidation of a protein in a protein composition and methods of preventing oxidation of a protein in a formulation.

公开(公告)号：US20210221892A1

公开(公告)日：2021-07-22

申请号：US17101966

申请日：2020-11-23

Applicant: Genentech, Inc.

Inventor： Ying YANG ,  Sreedhara ALAVATTAM

IPC: C07K16/28 ,  A61K39/395

Abstract: The invention provides stable aqueous pharmaceutical formulations comprising an anti-PDL1 antibody. The invention also provides methods for making such formulations and methods of using such formulations.

公开(公告)号：US20140322203A1

公开(公告)日：2014-10-30

申请号：US14207901

申请日：2014-03-13

Applicant: Genentech, Inc.

Inventor： Sreedhara ALAVATTAM ,  Mary MALLANEY ,  Parbir GREWAL

IPC: A61K47/22 ,  A61K39/395 ,  C07K16/00

CPC classification number: A61K47/22 ,  A61K39/39591 ,  A61K47/183 ,  C07K16/00 ,  C07K16/2878

Abstract: The invention provides formulations comprising a protein in combination with a compound that prevents oxidation of the protein. The invention also provides methods for making such formulations and methods of using such formulations. The invention further provides methods of screening for compounds that prevent oxidation of a protein in a protein composition and methods of preventing oxidation of a protein in a formulation.

Abstract translation: 本发明提供了包含与防止蛋白质氧化的化合物组合的蛋白质的制剂。 本发明还提供了制备这些制剂的方法和使用这些制剂的方法。 本发明进一步提供筛选蛋白质组合物中的蛋白质的氧化化合物的方法和防止制剂中的蛋白质氧化的方法。

公开(公告)号：US20240010732A1

公开(公告)日：2024-01-11

申请号：US18364312

申请日：2023-08-02

Applicant: Genentech, Inc.

Inventor： Ying YANG ,  Sreedhara ALAVATTAM

IPC: C07K16/28 ,  A61K39/395

CPC classification number: C07K16/2827 ,  A61K39/39591 ,  A61K2039/505 ,  C07K2317/76 ,  C07K2317/41

Abstract: The invention provides stable aqueous pharmaceutical formulations comprising an anti-PDL1 antibody. The invention also provides methods for making such formulations and methods of using such formulations.

公开(公告)号：US20160108125A1

公开(公告)日：2016-04-21

申请号：US14724568

申请日：2015-05-28

Applicant: Genentech, Inc.

Inventor： Sreedhara ALAVATTAM ,  Mary MALLANEY ,  Parbir GREWAL

IPC: C07K16/28 ,  G01N33/68 ,  C07K16/24

CPC classification number: A61K31/405 ,  A61K39/39533 ,  A61K39/39591 ,  A61K2039/505 ,  C07K16/241 ,  C07K16/2878 ,  C07K2317/52 ,  C07K2317/55 ,  C12Q1/28 ,  G01N33/6854

Abstract: The invention provides formulations comprising a protein in combination with a compound that prevents oxidation of the protein. The invention also provides methods for making such formulations and methods of using such formulations. The invention further provides methods of screening for compounds that prevent oxidation of a protein in a protein composition and methods of preventing oxidation of a protein in a formulation.

Abstract translation: 本发明提供了包含与防止蛋白质氧化的化合物组合的蛋白质的制剂。 本发明还提供了制备这些制剂的方法和使用这些制剂的方法。 本发明进一步提供筛选蛋白质组合物中的蛋白质的氧化化合物的方法和防止制剂中的蛋白质氧化的方法。

公开(公告)号：US20210155715A1

公开(公告)日：2021-05-27

申请号：US17168621

申请日：2021-02-05

Applicant: Genentech, Inc.

Inventor： Cleo SALISBURY ,  Vikas SHARMA ,  Sreedhara ALAVATTAM

IPC: C07K16/42

Abstract: The present disclosure provides methods and formulations comprising a polypeptide comprising solvent accessible amino acid residues susceptible to oxidation wherein N-acetyl-DL-tryptophan (NAT) and/or L-methionine is used to prevent oxidation of the polypeptide.

公开(公告)号：US20180318256A1

公开(公告)日：2018-11-08

申请号：US15821470

申请日：2017-11-22

Applicant: Genentech, Inc.

Inventor： Sreedhara ALAVATTAM ,  Mary MALLANEY ,  Parbir GREWAL

IPC: A61K31/405 ,  G01N33/68 ,  C12Q1/28 ,  C07K16/28 ,  A61K39/395 ,  C07K16/24 ,  A61K39/00

CPC classification number: A61K31/405 ,  A61K39/39533 ,  A61K39/39591 ,  A61K2039/505 ,  C07K16/241 ,  C07K16/2878 ,  C07K2317/52 ,  C07K2317/55 ,  C12Q1/28 ,  G01N33/6854

Abstract: The invention provides formulations comprising a protein in combination with a compound that prevents oxidation of the protein. The invention also provides methods for making such formulations and methods of using such formulations. The invention further provides methods of screening for compounds that prevent oxidation of a protein in a protein composition and methods of preventing oxidation of a protein in a formulation.

公开(公告)号：US20140314778A1

公开(公告)日：2014-10-23

申请号：US14207911

申请日：2014-03-13

Applicant: Genentech, Inc.

Inventor： Sreedhara ALAVATTAM ,  Mary MALLANEY ,  Parbir GREWAL

IPC: A61K39/395

CPC classification number: A61K31/405 ,  A61K39/39533 ,  A61K39/39591 ,  A61K2039/505 ,  C07K16/241 ,  C07K16/2878 ,  C07K2317/52 ,  C07K2317/55 ,  C12Q1/28 ,  G01N33/6854

Abstract: The invention provides formulations comprising a protein in combination with a compound that prevents oxidation of the protein. The invention also provides methods for making such formulations and methods of using such formulations. The invention further provides methods of screening for compounds that prevent oxidation of a protein in a protein composition and methods of preventing oxidation of a protein in a formulation.

公开(公告)号：US20250145717A1

公开(公告)日：2025-05-08

申请号：US18900229

申请日：2024-09-27

Applicant: Genentech, Inc.

Inventor： Ying YANG ,  Sreedhara ALAVATTAM

IPC: C07K16/28 ,  A61K39/00 ,  A61K39/395

Abstract: The invention provides stable aqueous pharmaceutical formulations comprising an anti-PDL1 antibody. The invention also provides methods for making such formulations and methods of using such formulations.

公开(公告)号：US20170196837A1

公开(公告)日：2017-07-13

申请号：US15385788

申请日：2016-12-20

Applicant: Genentech, Inc.

Inventor： Sreedhara ALAVATTAM ,  Mary MALLANEY ,  Parbir GREWAL

IPC: A61K31/405 ,  C12Q1/28 ,  A61K39/395

CPC classification number: A61K31/405 ,  A61K39/39533 ,  A61K39/39591 ,  A61K2039/505 ,  C07K16/241 ,  C07K16/2878 ,  C07K2317/52 ,  C07K2317/55 ,  C12Q1/28 ,  G01N33/6854

Abstract: The invention provides formulations comprising a protein in combination with a compound that prevents oxidation of the protein. The invention also provides methods for making such formulations and methods of using such formulations. The invention further provides methods of screening for compounds that prevent oxidation of a protein in a protein composition and methods of preventing oxidation of a protein in a formulation.