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公开(公告)号：US09597411B2
公开(公告)日：2017-03-21
申请号：US14705525
申请日：2015-05-06
Applicant: GENENTECH, INC.
Inventor： Youjun Chen , William Mallet , Paul Polakis , Christine Tan , Jyoti Asundi , Suzanna Clark
CPC classification number: C07K16/3053 , A61K31/5383 , A61K39/39558 , A61K45/06 , A61K47/6809 , A61K47/6849 , A61K47/6889 , A61K51/1093 , C07K16/2854 , C07K16/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/77 , G01N33/58 , G01N33/60
Abstract: The invention provides anti-PMEL17 antibodies and immunoconjugates and methods of using the same.
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公开(公告)号：US20150183883A1
公开(公告)日：2015-07-02
申请号：US14418314
申请日：2013-08-01
Applicant: Genentech, Inc.
Inventor： Jyoti Asundi , Suzanna Clark , Paul Polakis
IPC: C07K16/30 , A61K31/551 , A61K45/06 , A61K47/48
CPC classification number: C07K16/3053 , A61K31/551 , A61K45/06 , A61K47/6803 , A61K47/6809 , A61K47/6849 , A61K47/6865 , A61K47/6889 , A61K2039/505 , C07K16/2869 , C07K2317/24 , C07K2317/56 , C07K2317/73
Abstract: The invention provides anti-ETBR antibodies and immunoconjugates and methods of using the same. In some embodiments, an immunoconjugate comprising an antibody that binds ETBR covalently attached to a cytotoxic agent is provided, wherein the antibody binds an epitope within amino acids 64 to 101 of SEQ ID NO: 10. In some embodiments, the cytotoxic agent is a pyrrolobenzodiazepine.
Abstract translation: 本发明提供抗ETBR抗体和免疫缀合物及其使用方法。 在一些实施方案中，提供了包含结合与细胞毒性剂共价连接的ETBR的抗体的免疫偶联物，其中所述抗体结合SEQ ID NO：10的氨基酸64至101内的表位。在一些实施方案中，细胞毒性剂是吡咯并苯并二氮杂 。
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公开(公告)号：US20140341916A1
公开(公告)日：2014-11-20
申请号：US14354362
申请日：2012-10-24
Applicant: Genentech, Inc.
Inventor： Paul Polakis , Jyoti Asundi , Suzanna Clark
IPC: C07K16/28 , A61K39/395 , C07K16/30 , A61K31/437 , A61K31/4523
CPC classification number: C07K16/2869 , A61K31/437 , A61K31/4523 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/73 , A61K2300/00
Abstract: The invention provides therapeutic combinations of anti-ETBR antibodies and MAP kinase inhibitors and methods of using the same to treat melanoma.
Abstract translation: 本发明提供抗ETBR抗体和MAP激酶抑制剂的治疗组合以及使用该组合治疗黑色素瘤的方法。
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公开(公告)号：US20170240645A1
公开(公告)日：2017-08-24
申请号：US15425527
申请日：2017-02-06
Applicant: GENENTECH, INC.
Inventor： Youjun Chen , William Mallet , Paul Polakis , Christine Tan , Jyoti Asundi , Suzanna Clark
IPC: C07K16/30 , A61K31/5383
CPC classification number: C07K16/3053 , A61K31/5383 , A61K39/39558 , A61K45/06 , A61K47/6809 , A61K47/6849 , A61K47/6889 , A61K51/1093 , C07K16/2854 , C07K16/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/77 , G01N33/58 , G01N33/60
Abstract: The invention provides anti-PMEL17 antibodies and immunoconjugates and methods of using the same.
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公开(公告)号：US09463251B2
公开(公告)日：2016-10-11
申请号：US14418310
申请日：2013-08-01
Applicant: Genentech, Inc.
Inventor： Jyoti Asundi , Suzanna Clark , Paul Polakis
IPC: A61K39/395 , A61K47/48 , C07K16/28 , C07K16/30 , A61K39/00
CPC classification number: A61K47/48384 , A61K39/39533 , A61K39/39558 , A61K47/6803 , A61K47/6809 , A61K47/6817 , A61K47/6849 , A61K2039/505 , A61K2039/507 , C07K16/2869 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/73
Abstract: The invention provides anti-ETBR antibodies and immunoconjugates and methods of using the same. In some embodiments, an immunoconjugate comprising an antibody that binds ETBR covalently attached to a cytotoxic agent is provided, wherein the antibody binds an epitope within amino acids 64 to 101 of SEQ ID NO: 10. In some embodiments, the cytotoxic agent is a nemorubicin derivative.
Abstract translation: 本发明提供抗ETBR抗体和免疫缀合物及其使用方法。 在一些实施方案中，提供包含结合与细胞毒性剂共价连接的ETBR的抗体的免疫偶联物，其中所述抗体结合SEQ ID NO：10的氨基酸64至101内的表位。在一些实施方案中，细胞毒性剂是尼莫尿 衍生物。
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Patent Agency Ranking
公开(公告)号：US09056910B2
公开(公告)日：2015-06-16
申请号：US13873462
申请日：2013-04-30
Applicant: Genentech, Inc.
Inventor： Youjun Chen , William Mallet , Paul Polakis , Christine Tan , Jyoti Asundi , Suzanna Clark
CPC classification number: C07K16/3053 , A61K31/5383 , A61K39/39558 , A61K45/06 , A61K47/6809 , A61K47/6849 , A61K47/6889 , A61K51/1093 , C07K16/2854 , C07K16/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/77 , G01N33/58 , G01N33/60
Abstract: The invention provides anti-PMEL17 antibodies and immunoconjugates and methods of using the same.
Abstract translation: 本发明提供抗PMEL17抗体和免疫缀合物及其使用方法。
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公开(公告)号：US10196454B2
公开(公告)日：2019-02-05
申请号：US15425527
申请日：2017-02-06
Applicant: GENENTECH, INC.
Inventor： Youjun Chen , William Mallet , Paul Polakis , Christine Tan , Jyoti Asundi , Suzanna Clark
IPC: A61K39/395 , C07K16/30 , A61K45/06 , A61K51/10 , G01N33/60 , C07K16/28 , A61K47/68 , A61K31/5383 , G01N33/58
Abstract: The invention provides anti-PMEL17 antibodies and immunoconjugates and methods of using the same.
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公开(公告)号：US09464141B2
公开(公告)日：2016-10-11
申请号：US14418314
申请日：2013-08-01
Applicant: Genentech, Inc.
Inventor： Jyoti Asundi , Suzanna Clark , Paul Polakis
IPC: A61K39/395 , C07K16/30 , C07K16/28 , A61K47/48 , A61K31/551 , A61K45/06 , A61K39/00
CPC classification number: C07K16/3053 , A61K31/551 , A61K45/06 , A61K47/6803 , A61K47/6809 , A61K47/6849 , A61K47/6865 , A61K47/6889 , A61K2039/505 , C07K16/2869 , C07K2317/24 , C07K2317/56 , C07K2317/73
Abstract: The invention provides anti-ETBR antibodies and immunoconjugates and methods of using the same. In some embodiments, an immunoconjugate comprising an antibody that binds ETBR covalently attached to a cytotoxic agent is provided, wherein the antibody binds an epitope within amino acids 64 to 101 of SEQ ID NO: 10. In some embodiments, the cytotoxic agent is a pyrrolobenzodiazepine.
Abstract translation: 本发明提供抗ETBR抗体和免疫缀合物及其使用方法。 在一些实施方案中，提供了包含结合与细胞毒性剂共价连接的ETBR的抗体的免疫偶联物，其中所述抗体结合SEQ ID NO：10的氨基酸64至101内的表位。在一些实施方案中，细胞毒性剂是吡咯并苯并二氮杂 。
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公开(公告)号：US20150374847A1
公开(公告)日：2015-12-31
申请号：US14705525
申请日：2015-05-06
Applicant: GENENTECH, INC.
Inventor： Youjun Chen , William Mallet , Paul Polakis , Christine Tan , Jyoti Asundi , Suzanna Clark
IPC: A61K47/48
CPC classification number: C07K16/3053 , A61K31/5383 , A61K39/39558 , A61K45/06 , A61K47/6809 , A61K47/6849 , A61K47/6889 , A61K51/1093 , C07K16/2854 , C07K16/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/77 , G01N33/58 , G01N33/60
Abstract: The invention provides anti-PMEL17 antibodies and immunoconjugates and methods of using the same.
Abstract translation: 本发明提供抗PMEL17抗体和免疫缀合物及其使用方法。
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公开(公告)号：US20150196660A1
公开(公告)日：2015-07-16
申请号：US14418310
申请日：2013-08-01
Applicant: Genentech, Inc.
Inventor： Jyoti Asundi , Suzanna Clark , Paul Polakis
IPC: A61K47/48 , A61K39/395 , C07K16/30
CPC classification number: A61K47/48384 , A61K39/39533 , A61K39/39558 , A61K47/6803 , A61K47/6809 , A61K47/6817 , A61K47/6849 , A61K2039/505 , A61K2039/507 , C07K16/2869 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/73
Abstract: The invention provides anti-ETBR antibodies and immunoconjugates and methods of using the same. In some embodiments, an immunoconjugate comprising an antibody that binds ETBR covalently attached to a cytotoxic agent is provided, wherein the antibody binds an epitope within amino acids 64 to 101 of SEQ ID NO: 10. In some embodiments, the cytotoxic agent is a nemorubicin derivative.
Abstract translation: 本发明提供抗ETBR抗体和免疫缀合物及其使用方法。 在一些实施方案中，提供包含结合与细胞毒性剂共价连接的ETBR的抗体的免疫偶联物，其中所述抗体结合SEQ ID NO：10的氨基酸64至101内的表位。在一些实施方案中，细胞毒性剂是尼莫尿 衍生物。
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