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公开(公告)号：USRE47223E1
公开(公告)日：2019-02-05
申请号：US14752767
申请日：2015-06-26
Applicant: Genentech, Inc.
Inventor： Mark S. Dennis , Paul Polakis , William Mallet
Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20140205616A1
公开(公告)日：2014-07-24
申请号：US14109213
申请日：2013-12-17
Applicant: Genentech, Inc.
Inventor： Mark Dennis , William Mallet , Paul Polakis
IPC: A61K47/48 , A61K31/337 , A61K31/513 , A61K31/537 , A61K31/519 , A61K31/517 , A61K31/7072 , A61K38/07 , A61K31/4196 , A61K31/555
CPC classification number: A61K47/6803 , A61K31/337 , A61K31/4025 , A61K31/4196 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/537 , A61K31/555 , A61K31/7068 , A61K31/7072 , A61K38/07 , A61K38/08 , A61K45/06 , A61K47/6817 , A61K47/6835 , A61K47/6851 , A61K2039/505 , C07K16/3015 , C07K16/303 , C07K16/3069 , C07K16/3092 , C07K2317/24 , C07K2317/55 , C07K2317/565 , Y10T428/13
Abstract: The invention is directed to antibody drug conjugate compositions of matter useful for the diagnosis and treatment of tumors in mammals and to methods of using those compositions of matter for the same.
Abstract translation: 本发明涉及可用于诊断和治疗哺乳动物肿瘤的物质的抗体药物共轭组合物，以及使用这些物质组合物的方法。
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公开(公告)号：US20140314794A1
公开(公告)日：2014-10-23
申请号：US14108820
申请日：2013-12-17
Applicant: Genentech, Inc.
Inventor： Mark Dennis , William Mallet , Paul Polakis
IPC: A61K47/48 , A61K38/08 , A61K45/06 , A61K31/4025
CPC classification number: A61K47/6803 , A61K31/337 , A61K31/4025 , A61K31/4196 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/537 , A61K31/555 , A61K31/7068 , A61K31/7072 , A61K38/07 , A61K38/08 , A61K45/06 , A61K47/6817 , A61K47/6835 , A61K47/6851 , A61K2039/505 , C07K16/3015 , C07K16/303 , C07K16/3069 , C07K16/3092 , C07K2317/24 , C07K2317/55 , C07K2317/565 , Y10T428/13
Abstract: The invention is directed to antibody drug conjugate compositions of matter useful for the diagnosis and treatment of tumors in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20140050744A1
公开(公告)日：2014-02-20
申请号：US13945052
申请日：2013-07-18
Applicant: Genentech, Inc.
Inventor： Mark Dennis , William Mallet , Paul Polakis
IPC: A61K47/48
CPC classification number: A61K47/6803 , A61K31/337 , A61K31/4025 , A61K31/4196 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/537 , A61K31/555 , A61K31/7068 , A61K31/7072 , A61K38/07 , A61K38/08 , A61K45/06 , A61K47/6817 , A61K47/6835 , A61K47/6851 , A61K2039/505 , C07K16/3015 , C07K16/303 , C07K16/3069 , C07K16/3092 , C07K2317/24 , C07K2317/55 , C07K2317/565 , Y10T428/13
Abstract: The invention is directed to antibody drug conjugate compositions of matter useful for the diagnosis and treatment of tumors in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US10196454B2
公开(公告)日：2019-02-05
申请号：US15425527
申请日：2017-02-06
Applicant: GENENTECH, INC.
Inventor： Youjun Chen , William Mallet , Paul Polakis , Christine Tan , Jyoti Asundi , Suzanna Clark
IPC: A61K39/395 , C07K16/30 , A61K45/06 , A61K51/10 , G01N33/60 , C07K16/28 , A61K47/68 , A61K31/5383 , G01N33/58
Abstract: The invention provides anti-PMEL17 antibodies and immunoconjugates and methods of using the same.
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Patent Agency Ranking
公开(公告)号：US20150374847A1
公开(公告)日：2015-12-31
申请号：US14705525
申请日：2015-05-06
Applicant: GENENTECH, INC.
Inventor： Youjun Chen , William Mallet , Paul Polakis , Christine Tan , Jyoti Asundi , Suzanna Clark
IPC: A61K47/48
CPC classification number: C07K16/3053 , A61K31/5383 , A61K39/39558 , A61K45/06 , A61K47/6809 , A61K47/6849 , A61K47/6889 , A61K51/1093 , C07K16/2854 , C07K16/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/77 , G01N33/58 , G01N33/60
Abstract: The invention provides anti-PMEL17 antibodies and immunoconjugates and methods of using the same.
Abstract translation: 本发明提供抗PMEL17抗体和免疫缀合物及其使用方法。
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公开(公告)号：USRE47194E1
公开(公告)日：2019-01-08
申请号：US14680457
申请日：2015-04-07
Applicant: Genentech, Inc.
Inventor： Jagath R. Junutula , William Mallet
Abstract: Cysteine engineered anti-MUC16 antibodies are engineered by replacing one or more amino acids of a parent anti-MUC16 antibody with non cross-linked, reactive cysteine amino acids. Methods of design, preparation, screening, and selection of the cysteine engineered anti-MUC16 antibodies are provided. Cysteine engineered anti-MUC16 antibodies (Ab) are conjugated with one or more drug moieties (D) through a linker (L) to form cysteine engineered anti-MUC16 antibody-drug conjugates having Formula I: Ab-(L-D)p I where p is 1 to 4. Diagnostic and therapeutic uses for cysteine engineered antibody drug compounds and compositions are disclosed.
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公开(公告)号：US09597411B2
公开(公告)日：2017-03-21
申请号：US14705525
申请日：2015-05-06
Applicant: GENENTECH, INC.
Inventor： Youjun Chen , William Mallet , Paul Polakis , Christine Tan , Jyoti Asundi , Suzanna Clark
CPC classification number: C07K16/3053 , A61K31/5383 , A61K39/39558 , A61K45/06 , A61K47/6809 , A61K47/6849 , A61K47/6889 , A61K51/1093 , C07K16/2854 , C07K16/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/77 , G01N33/58 , G01N33/60
Abstract: The invention provides anti-PMEL17 antibodies and immunoconjugates and methods of using the same.
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公开(公告)号：US20170240645A1
公开(公告)日：2017-08-24
申请号：US15425527
申请日：2017-02-06
Applicant: GENENTECH, INC.
Inventor： Youjun Chen , William Mallet , Paul Polakis , Christine Tan , Jyoti Asundi , Suzanna Clark
IPC: C07K16/30 , A61K31/5383
CPC classification number: C07K16/3053 , A61K31/5383 , A61K39/39558 , A61K45/06 , A61K47/6809 , A61K47/6849 , A61K47/6889 , A61K51/1093 , C07K16/2854 , C07K16/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/77 , G01N33/58 , G01N33/60
Abstract: The invention provides anti-PMEL17 antibodies and immunoconjugates and methods of using the same.
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公开(公告)号：US09056910B2
公开(公告)日：2015-06-16
申请号：US13873462
申请日：2013-04-30
Applicant: Genentech, Inc.
Inventor： Youjun Chen , William Mallet , Paul Polakis , Christine Tan , Jyoti Asundi , Suzanna Clark
CPC classification number: C07K16/3053 , A61K31/5383 , A61K39/39558 , A61K45/06 , A61K47/6809 , A61K47/6849 , A61K47/6889 , A61K51/1093 , C07K16/2854 , C07K16/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/77 , G01N33/58 , G01N33/60
Abstract: The invention provides anti-PMEL17 antibodies and immunoconjugates and methods of using the same.
Abstract translation: 本发明提供抗PMEL17抗体和免疫缀合物及其使用方法。
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