公开(公告)号：US20210299110A1

公开(公告)日：2021-09-30

申请号：US17178021

申请日：2021-02-17

Applicant: Genentech, Inc.

Inventor： Timothy HEFFRON ,  Sushant MALHOTRA ,  BinQing WEI ,  Bryan CHAN ,  Lewis GAZZARD ,  Emanuela GANCIA ,  Michael LAINCHBURY ,  Andrew MADIN ,  Eileen SEWARD ,  Yonghan HU

IPC: A61K31/437 ,  A61K31/444 ,  A61K31/506 ,  A61K31/513 ,  A61K31/5377 ,  C07D471/04

Abstract: Azaindole compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the azaindole compounds.

公开(公告)号：US20200000780A1

公开(公告)日：2020-01-02

申请号：US16568459

申请日：2019-09-12

Applicant: Genentech, Inc.

Inventor： Timothy HEFFRON ,  Sushant MALHOTRA ,  BinQing WEI ,  Bryan CHAN ,  Lewis GAZZARD ,  Emanuela GANCIA ,  Michael LAINCHBURY ,  Andrew MADIN ,  Eileen SEWARD ,  Yonghan HU

IPC: A61K31/437 ,  A61K31/444 ,  A61K31/5377 ,  C07D471/04 ,  A61K31/506 ,  A61K31/513

Abstract: Azaindole compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the azaindole compounds.