公开(公告)号：US20240383915A1

公开(公告)日：2024-11-21

申请号：US18554438

申请日：2022-04-06

Applicant: Genentech, Inc.

Inventor： Lewis J. GAZZARD ,  Samantha Alyson GREEN ,  Elizabeth H. KELLEY ,  Matthew Leo LANDRY ,  Sushant MALHOTRA ,  Benjamin David RAVETZ ,  Michael SIU ,  Jack Alexander TERRETT ,  BinQing WEI ,  Steven DO ,  Yun-Xing CHENG ,  Limin CHENG ,  Jianfeng XIN ,  Mingtao HE ,  Guosheng WU ,  Yinlei SUN ,  Cheng SHAO ,  Aijun LU ,  Yulai ZHANG

IPC: C07D498/04 ,  A61K31/553 ,  A61K45/06 ,  C07D519/00

Abstract: Provided herein are acyclic oxazepinyl compounds useful in the treatment on cancers.

公开(公告)号：US20230279012A1

公开(公告)日：2023-09-07

申请号：US18069099

申请日：2022-12-20

Applicant: Genentech, Inc.

Inventor： James John CRAWFORD ,  Daniel Fred ORTWINE ,  BinQing WEI ,  Wendy B. YOUNG

IPC: C07D487/04 ,  C07D487/14 ,  C07D471/04 ,  C07D471/14 ,  C07D495/04 ,  C07D519/00 ,  A61P37/00 ,  A61P35/00 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/5383 ,  A61K45/06 ,  C07D495/14 ,  C07D498/04 ,  A61K31/4995 ,  A61K31/501 ,  C07D487/08 ,  C07D513/04 ,  A61K31/495 ,  A61K9/20

CPC classification number: C07D487/04 ,  C07D487/14 ,  C07D471/04 ,  C07D471/14 ,  C07D495/04 ,  C07D519/00 ,  A61P37/00 ,  A61P35/00 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/5383 ,  A61K45/06 ,  C07D495/14 ,  C07D498/04 ,  A61K31/4995 ,  A61K31/501 ,  C07D487/08 ,  C07D513/04 ,  A61K31/495 ,  A61K9/20

Abstract: Heteroaryl pyridone and aza-pyridone compounds are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using heteroaryl pyridone and aza-pyridone compounds for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

公开(公告)号：US20240270747A1

公开(公告)日：2024-08-15

申请号：US18523284

申请日：2023-11-29

Applicant: Genentech, Inc.

Inventor： James John CRAWFORD ,  Daniel Fred ORTWINE ,  BinQing WEI ,  Wendy B. YOUNG

IPC: C07D487/04 ,  A61K9/20 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/4995 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/5383 ,  A61K45/06 ,  A61P35/00 ,  A61P37/00 ,  C07D471/04 ,  C07D471/14 ,  C07D487/08 ,  C07D487/14 ,  C07D495/04 ,  C07D495/14 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

CPC classification number: C07D487/04 ,  A61K9/20 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/4995 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/5383 ,  A61K45/06 ,  A61P35/00 ,  A61P37/00 ,  C07D471/04 ,  C07D471/14 ,  C07D487/08 ,  C07D487/14 ,  C07D495/04 ,  C07D495/14 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

Abstract: Heteroaryl pyridone and aza-pyridone compounds are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using heteroaryl pyridone and aza-pyridone compounds for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

公开(公告)号：US20210299110A1

公开(公告)日：2021-09-30

申请号：US17178021

申请日：2021-02-17

Applicant: Genentech, Inc.

Inventor： Timothy HEFFRON ,  Sushant MALHOTRA ,  BinQing WEI ,  Bryan CHAN ,  Lewis GAZZARD ,  Emanuela GANCIA ,  Michael LAINCHBURY ,  Andrew MADIN ,  Eileen SEWARD ,  Yonghan HU

IPC: A61K31/437 ,  A61K31/444 ,  A61K31/506 ,  A61K31/513 ,  A61K31/5377 ,  C07D471/04

Abstract: Azaindole compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the azaindole compounds.

公开(公告)号：US20200000780A1

公开(公告)日：2020-01-02

申请号：US16568459

申请日：2019-09-12

Applicant: Genentech, Inc.

Inventor： Timothy HEFFRON ,  Sushant MALHOTRA ,  BinQing WEI ,  Bryan CHAN ,  Lewis GAZZARD ,  Emanuela GANCIA ,  Michael LAINCHBURY ,  Andrew MADIN ,  Eileen SEWARD ,  Yonghan HU

IPC: A61K31/437 ,  A61K31/444 ,  A61K31/5377 ,  C07D471/04 ,  A61K31/506 ,  A61K31/513

Abstract: Azaindole compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the azaindole compounds.

公开(公告)号：US20240228512A1

公开(公告)日：2024-07-11

申请号：US18490736

申请日：2023-10-19

Applicant: Genentech, Inc.

Inventor： Benjamin David RAVETZ ,  Jack Alexander TERRETT ,  BinQing WEI ,  Mingshuo ZENG ,  Cheng SHAO ,  Yinlei SUN

IPC: C07D519/00 ,  A61K31/553 ,  A61P31/00 ,  C07D498/16

CPC classification number: C07D519/00 ,  A61K31/553 ,  A61P31/00 ,  C07D498/16

Abstract: Provided herein are acyclic oxazepinyl compounds comprising a 6-aza moiety that are useful in the treatment of cancers.

公开(公告)号：US20210079002A1

公开(公告)日：2021-03-18

申请号：US17001205

申请日：2020-08-24

Applicant: Genentech, Inc.

Inventor： James John CRAWFORD ,  Daniel Fred ORTWINE ,  BinQing WEI ,  Wendy B. YOUNG

IPC: C07D487/04 ,  C07D487/14 ,  C07D471/04 ,  C07D471/14 ,  C07D495/04 ,  C07D519/00 ,  A61P37/00 ,  A61P35/00 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/5383 ,  A61K45/06 ,  C07D495/14 ,  C07D498/04 ,  A61K31/4995 ,  A61K31/501 ,  C07D487/08 ,  C07D513/04 ,  A61K31/495 ,  A61K9/20

Abstract: Heteroaryl pyridone and aza-pyridone compounds are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using heteroaryl pyridone and aza-pyridone compounds for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

公开(公告)号：US20200062769A1

公开(公告)日：2020-02-27

申请号：US16670898

申请日：2019-10-31

Applicant: Genentech, Inc.

Inventor： James John CRAWFORD ,  Daniel Fred ORTWINE ,  BinQing WEI ,  Wendy B. YOUNG

IPC: C07D487/04 ,  A61K9/20 ,  A61K31/495 ,  C07D513/04 ,  C07D487/08 ,  A61K31/501 ,  A61K31/4995 ,  C07D498/04 ,  C07D495/14 ,  A61K45/06 ,  A61K31/5383 ,  A61K31/5377 ,  A61K31/53 ,  A61K31/506 ,  A61K31/5025 ,  A61K31/4985 ,  A61K31/496 ,  C07D519/00 ,  C07D495/04 ,  C07D471/14 ,  C07D471/04 ,  C07D487/14 ,  A61P35/00 ,  A61P37/00

Abstract: Heteroaryl pyridone and aza-pyridone compounds are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using heteroaryl pyridone and aza-pyridone compounds for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.