公开(公告)号：US20240166595A1

公开(公告)日：2024-05-23

申请号：US18519529

申请日：2023-11-27

Applicant: Genentech, Inc.

Inventor： Rémy Angelaud ,  Tobias Bruetsch ,  Francis Gosselin ,  Chong Han ,  Alfred Stutz

IPC: C07C313/06 ,  B01J23/72 ,  C07C215/08 ,  C07D263/20 ,  C07D498/04 ,  C07F7/18

CPC classification number: C07C313/06 ,  B01J23/72 ,  C07C215/08 ,  C07D263/20 ,  C07D498/04 ,  C07F7/1892

Abstract: Methods of making benzoxazepin oxazolidinone compounds as well as synthetic intermediates are described, including compound (10-2) and compound 18:

公开(公告)号：US11873305B2

公开(公告)日：2024-01-16

申请号：US17360593

申请日：2021-06-28

Applicant: Genentech, Inc. ,  Hoffmann-La Roche Inc.

Inventor： Haiming Zhang ,  Jie Xu ,  Georg Wuitschik ,  Remy Angelaud ,  Sebastian Herold ,  Alfred Stutz ,  Tobias Bruetsch ,  Johannes Burkhard

IPC: C07D209/10 ,  C07D487/04

CPC classification number: C07D487/04

Abstract: Provided herein are processes for the preparation of indolyl intermediates using Wenker Synthesis for the total synthesis of SERD compounds useful in the treatment of cancer.