公开(公告)号：US20040018980A1

公开(公告)日：2004-01-29

申请号：US10461060

申请日：2003-06-13

Applicant: Genentech, Inc.

Inventor： Austin L. Gurney ,  Caroline Hebert ,  William J. Henzel ,  Rhona Kabakoff ,  David L. Shelton ,  Daniel B. Tumas

IPC: A61K038/17

CPC classification number: C07K14/4703 ,  A61K38/00 ,  A61K39/00 ,  C12N2799/026

Abstract: The present invention is directed to novel polypeptides, designated FIZZ, which are secreted low molecular weight molecules showing no significant sequence homology to any known protein, and nucleic acid sequences encoding such proteins. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptide of the present invention fused to heterologous polypeptide sequences, and antibodies which bind to the polypeptides of the present invention. Methods of using FIZZ polypeptides to treat various neurotrophin-related conditions are further provided.

Abstract translation: 本发明涉及称为FIZZ的新型多肽，其是分泌的低分子量分子，与任何已知蛋白质没有显着的序列同源性，以及编码这种蛋白质的核酸序列。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，以及结合本发明多肽的抗体。 进一步提供使用FIZZ多肽治疗各种神经营养因子相关病症的方法。