公开(公告)号：US12071422B2

公开(公告)日：2024-08-27

申请号：US18164302

申请日：2023-02-03

申请人： Genentech, Inc. ,  Hoffmann-La Roche Inc.

发明人： Rene Lebl ,  Ngiap Kie Lim ,  Roland Christoph Meier ,  Ugo Jonathan Orcel ,  Joerg Sedelmeier ,  Jeff Shen ,  Lauren Elizabeth Sirois ,  Jacob C. Timmerman ,  Etienne Trachsel ,  Nicholas Andrew White ,  Jie Xu ,  Haiming Zhang ,  Stephan Bachmann ,  Thomas Michael Bass ,  Raphael Bigler ,  Johannes Adrian Burkhard ,  Kyle Bradley Pascual Clagg ,  Francis Gosselin ,  Chong Han ,  Dainis Kaldre ,  Sean M. Kelly ,  Sebastian Herold ,  Christian Leitner

IPC分类号： C07D401/04 ,  B01J23/44 ,  B01J23/755

CPC分类号： C07D401/04 ,  B01J23/44 ,  B01J23/755

摘要： Provided herein are methods to synthesize compounds useful in the treatment of cancer where such compounds comprise a quinazolinyl core moiety and at least one stereoisomeric or atropisomeric moiety.

公开(公告)号：US20220081413A1

公开(公告)日：2022-03-17

申请号：US17398345

申请日：2021-08-10

申请人： Genentech, Inc. ,  Hoffmann-La Roche Inc.

发明人： Ngiap-Kie Lim ,  Jeff Shen ,  Lauren E. Sirois ,  Jacob C. Timmerman ,  Etienne Trachsel ,  Nicholas A. White ,  Jie Xu ,  Haiming Zhang ,  Stephan Bachmann ,  Raphael Bigler ,  Kyle Bradley Pascual Clagg ,  Antonio Dipasquale ,  Francis Gosselin ,  Ugo Jonathan Orcel ,  Roland Christoph Meier

IPC分类号： C07D401/14

摘要： Provided herein are methods of synthesizing quinazoline compounds comprising at least one atropisomeric center.