公开(公告)号：US20210207219A1

公开(公告)日：2021-07-08

申请号：US17147061

申请日：2021-01-12

Applicant: Genentech, Inc.

Inventor： Brian Yaspan ,  Robert Royal Graham ,  Amy Dressen ,  Zhengrong Li ,  Erich Strauss ,  Teodorica Bugawan

IPC: C12Q1/6883

Abstract: The invention provides methods and compositions for treating various degenerative diseases (e.g., AMD) with a factor D inhibitor (e.g., anti-factor D antibody or antigen-binding fragment thereof). Also provided are methods of selecting or identifying patients for treatment with a factor D inhibitor. Methods include the use of prognostic and/or predictive biomarkers.

公开(公告)号：US20180163262A1

公开(公告)日：2018-06-14

申请号：US15653460

申请日：2017-07-18

Applicant: Genentech, Inc.

Inventor： Timothy W. Behrens ,  Robert Royal Graham

IPC: C12Q1/6827 ,  C12Q1/6883

CPC classification number: C12Q1/6827 ,  C12Q1/6883 ,  C12Q2600/156

Abstract: The present invention relates to methods for identifying individuals with intermediate age-related macular degeneration (AMD) who possess a greater risk of progression to advanced AMD, using a polygenic score calculated based on the results of genome-wide gene association studies, using thousands of single-nucleotide polymorphisms (SNPs).

公开(公告)号：US20150044205A1

公开(公告)日：2015-02-12

申请号：US14456268

申请日：2014-08-11

Applicant: Genentech,Inc.

Inventor： Brian Yaspan ,  Robert Royal Graham ,  Amy Dressen ,  Zhengrong Li ,  Erich Strauss ,  Teodorica Bugawan

IPC: C12Q1/68 ,  C07K16/40

CPC classification number: C12Q1/6883 ,  A61K2039/505 ,  C07K16/40 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/156

Abstract: The invention provides methods and compositions for treating various degenerative diseases (e.g., AMD) with a factor D inhibitor (e.g., anti-factor D antibody or antigen-binding fragment thereof). Also provided are methods of selecting or identifying patients for treatment with a factor D inhibitor. Methods include the use of prognostic and/or predictive biomarkers.

Abstract translation: 本发明提供用因子D抑制剂（例如，抗因子D抗体或其抗原结合片段）治疗各种退行性疾病（例如AMD）的方法和组合物。 还提供了选择或鉴定患者用因子D抑制剂治疗的方法。 方法包括使用预后和/或预测生物标志物。

公开(公告)号：US20140286947A1

公开(公告)日：2014-09-25

申请号：US13999496

申请日：2014-03-04

Applicant: Genentech, Inc.

Inventor： Timothy W. Behrens ,  Robert Royal Graham

IPC: C12Q1/68

CPC classification number: C12Q1/6827 ,  C12Q1/6883 ,  C12Q2600/156

Abstract: The present invention relates to methods for identifying individuals with intermediate age-related macular degeneration (AMD) who possess a greater risk of progression to advanced AMD, using a polygenic score calculated based on the results of genome-wide gene association studies, using thousands of single-nucleotide polymorphisms (SNPs).

Abstract translation: 本发明涉及使用基于全基因组的基因关联研究的结果计算的多基因评分，使用数千种以上的基因组全基因关联研究，鉴定具有中度年龄相关性黄斑变性（AMD）的个体，其具有进展为高级AMD的更大风险 单核苷酸多态性（SNP）。

公开(公告)号：US10947591B2

公开(公告)日：2021-03-16

申请号：US16105952

申请日：2018-08-20

Applicant: GENENTECH, INC.

Inventor： Brian Yaspan ,  Robert Royal Graham ,  Amy Dressen ,  Zhengrong Li ,  Erich Strauss ,  Teodorica Bugawan

IPC: C12Q1/6883 ,  C07K16/40 ,  A61K39/00

Abstract: The invention provides methods and compositions for treating various degenerative diseases (e.g., AMD) with a factor D inhibitor (e.g., anti-factor D antibody or antigen-binding fragment thereof). Also provided are methods of selecting or identifying patients for treatment with a factor D inhibitor. Methods include the use of prognostic and/or predictive biomarkers.

公开(公告)号：US10093978B2

公开(公告)日：2018-10-09

申请号：US14456268

申请日：2014-08-11

Applicant: Genentech, Inc.

Inventor： Brian Yaspan ,  Robert Royal Graham ,  Amy Dressen ,  Zhengrong Li ,  Erich Strauss ,  Teodorica Bugawan

IPC: C12Q1/6883 ,  C07K16/40 ,  A61K39/00

Abstract: The invention provides methods and compositions for treating various degenerative diseases (e.g., AMD) with a factor D inhibitor (e.g., anti-factor D antibody or antigen-binding fragment thereof). Also provided are methods of selecting or identifying patients for treatment with a factor D inhibitor. Methods include the use of prognostic and/or predictive biomarkers.