公开(公告)号：US10294454B2

公开(公告)日：2019-05-21

申请号：US15245584

申请日：2016-08-24

Applicant: General Electric Company

Inventor： Ernest William Kovacs ,  Anup Sood ,  Reginald Donovan Smith ,  Evelina Roxana Loghin ,  Padmaparna Chadhuri ,  Vandana Keskar ,  Chrystal Mae Chadwick ,  Martin James Brown

IPC: A61K38/00 ,  C12N5/00 ,  C12N5/02 ,  C12N5/0783 ,  C07K16/28

Abstract: Provided are methods and kits for activating T cells, the method comprising providing a population of T cells, adding a plurality of first agents, where the first agent comprises a T-cell activator and a first binder moiety, and adding a second agent comprising a plurality of capture oligomers, where at least a segment of at least one of the plurality of capture oligomers is capable of associating with the first binder moiety. The method further comprises incubating the population of T cells, whereby at least a portion of the population of T cells is activated.

公开(公告)号：US20180057791A1

公开(公告)日：2018-03-01

申请号：US15245584

申请日：2016-08-24

Applicant: General Electric Company

Inventor： Ernest William Kovacs ,  Anup Sood ,  Reginald Donovan Smith ,  Evelina Roxana Loghin ,  Padmaparna Chadhuri ,  Vandana Keskar ,  Chrystal Mae Chadwick ,  Martin James Brown

IPC: C12N5/0783 ,  C07K16/28

CPC classification number: C12N5/0636 ,  C07K16/2809 ,  C07K16/2818 ,  C12N2501/51 ,  C12N2501/515

Abstract: Provided are methods and kits for activating T cells, the method comprising providing a population of T cells, adding a plurality of first agents, where the first agent comprises a T-cell activator and a first binder moiety, and adding a second agent comprising a plurality of capture oligomers, where at least a segment of at least one of the plurality of capture oligomers is capable of associating with the first binder moiety. The method further comprises incubating the population of T cells, whereby at least a portion of the population of T cells is activated.

公开(公告)号：US11512288B2

公开(公告)日：2022-11-29

申请号：US16339077

申请日：2017-08-24

Applicant: General Electric Company

Inventor： Ernest William Kovacs ,  Anup Sood ,  Reginald Donovan Smith ,  Evelina Roxana Loghin ,  Padmaparna Chaudhuri ,  Vandana Keskar ,  Chrystal Mae Chadwick ,  Martin James Brown

IPC: C12N5/0783 ,  C07K16/28

Abstract: Provided herein are methods of activating immune cells. The method includes providing a population of immune cells and contacting the population of immune cells with a first agent and a second agent. The first agent includes an immune cell activator attached to a first binder moiety, and the second agent includes at least one capture oligomer. The at least one capture oligomer is capable of associating with the first binder moiety. Also provided are kits for activating immune cells.

公开(公告)号：US20200181572A1

公开(公告)日：2020-06-11

申请号：US16339077

申请日：2017-08-24

Applicant: General Electric Company

Inventor： Ernest William Kovacs ,  Anup Sood ,  Reginald Donovan Smith ,  Evelina Roxana Loghin ,  Padmaparna Chaudhuri ,  Vandana Keskar ,  Chrystal Mae Chadwick ,  Martin James Brown

IPC: C12N5/0783 ,  C07K16/28

Abstract: Provided herein are methods of activating immune cells. The method includes providing a population of immune cells and contacting the population of immune cells with a first agent and a second agent. The first agent includes an immune cell activator attached to a first binder moiety, and the second agent includes at least one capture oligomer. The at least one capture oligomer is capable of associating with the first binder moiety. Also provided are kits for activating immune cells.